Prevalence of SARS-CoV-2 among high-risk populations in Lomé (Togo) in 2020.
Prevalence of SARS-CoV-2 among high-risk populations in Lomé (Togo) in 2020.
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DOI：
10.1371/journal.pone.0242124
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发表时间：
2020
期刊：
影响因子：
3.7
通讯作者：
Ekouevi DK
中科院分区：
文献类型：
--
作者：
Halatoko WA;Konu YR;Gbeasor-Komlanvi FA;Sadio AJ;Tchankoni MK;Komlanvi KS;Salou M;Dorkenoo AM;Maman I;Agbobli A;Wateba MI;Adjoh KS;Goeh-Akue E;Kao YB;Kpeto I;Pana P;Kinde-Sossou R;Tamekloe A;Nayo-Apétsianyi J;Assane SH;Prine-David M;Awoussi SM;Djibril M;Mijiyawa M;Dagnra AC;Ekouevi DK
2019年12月，COVID-19疫情在中国爆发并迅速蔓延至全球，并于2020年3月重新分类为大流行。多哥于3月5日宣布首例COVID-19病例。两个月后，几乎没有数据可以描述新型冠状病毒在该国的传播情况。该调查旨在估计洛美高风险人群中SARS-CoV-2的流行率。从2020年4月23日到2020年5月8日，我们从五个部门招募了参与者样本：医疗保健，航空运输，警察，公路运输和非正式。我们收集口咽拭子，通过实时逆转录聚合酶链反应（rRT-PCR）进行直接检测，并通过血清学试验进行抗体检测。感染的总体患病率（当前和过去）由两种检测的阳性定义。共纳入955名中位年龄为36岁（IQR 32-43）的参与者，71.6%（n = 684）为男性。约22.1%（n = 212）来自航空运输部门，20.5%（n = 196）来自警察部门，38.7%（n = 370）来自卫生部门。7名参与者（0.7%，95%CI：0.3-1.6%）在招募时的rRT-PCR检测结果为阳性，9名参与者（0.9%，95%CI：0.4-1.8%）的抗SARS-CoV-2 IgM或IgG血清阳性。我们发现总患病率为1.6%（n = 15），95%CI：0.9- 2.6%。洛美高风险人群中SARS-CoV-2感染的流行率相对较低，这可以用多哥政府采取的各种措施来解释。因此，我们建议进行有针对性的筛查。
In December 2019, the COVID-19 outbreak began in China and quickly spread throughout the world and was reclassified as a pandemic in March 2020. The first case of COVID-19 was declared in Togo on March 5. Two months later, few data were available to describe the circulation of the new coronavirus in the country. This survey aimed to estimate the prevalence of SARS-CoV-2 in high-risk populations in Lomé. From April 23, 2020, to May 8, 2020, we recruited a sample of participants from five sectors: health care, air transport, police, road transport and informal. We collected oropharyngeal swabs for direct detection through real-time reverse transcription polymerase chain reaction (rRT-PCR) and blood for antibody detection by serological tests. The overall prevalence (current and past) of infection was defined by positivity for both tests. A total of 955 participants with a median age of 36 (IQR 32–43) were included, and 71.6% (n = 684) were men. Approximately 22.1% (n = 212) were from the air transport sector, 20.5% (n = 196) were from the police sector, and 38.7% (n = 370) were from the health sector. Seven participants (0.7%, 95% CI: 0.3–1.6%) had a positive rRT-PCR test result at the time of recruitment, and nine (0.9%, 95% CI: 0.4–1.8%) were seropositive for IgM or IgG against SARS-CoV-2. We found an overall prevalence of 1.6% (n = 15), 95% CI: 0.9–2.6%. The prevalence of SARS-CoV-2 infection among high-risk populations in Lomé was relatively low and could be explained by the various measures taken by the Togolese government. Therefore, we recommend targeted screening.
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