Novel equation to determine the hepatic triglyceride concentration in humans by MRI: diagnosis and monitoring of NAFLD in obese patients before and after bariatric surgery.
Novel equation to determine the hepatic triglyceride concentration in humans by MRI: diagnosis and monitoring of NAFLD in obese patients before and after bariatric surgery.
复制标题
DOI：
10.1186/s12916-014-0137-y
复制
发表时间：
2014-08-26
期刊：
影响因子：
9.3
通讯作者：
Banales JM
中科院分区：
文献类型：
--
作者：
Jiménez-Agüero R;Emparanza JI;Beguiristain A;Bujanda L;Alustiza JM;García E;Hijona E;Gallego L;Sánchez-González J;Perugorria MJ;Asensio JI;Larburu S;Garmendia M;Larzabal M;Portillo MP;Aguirre L;Banales JM
非酒精性脂肪性肝病（NAFLD）是由肝细胞内脂质异常积聚引起的。在发达国家，与肥胖相关的脂肪肝患病率正在上升，它是非酒精性脂肪性肝炎（NASH）、肝硬化和肝细胞癌的一个危险因素。由于NAFLD在诊断时通常无症状，因此在诊断、治疗和控制疾病进展方面，需要新的非侵入性方法来确定肝脏脂质含量。在这里，我们研究了磁共振成像（MRI）在定量和监测人类肝脏甘油三酯浓度方面的潜力。对129例连续成年患者（肥胖97例，非肥胖32例）进行了诊断准确性的前瞻性研究，比较多回声MRI脂肪分数、组织病理学估计的脂肪变性等级和肝脏甘油三酯浓度的生化测量（即Folch值）。MRI脂肪分数与组织病理学估计的0 - 3级脂肪变性程度呈正相关。然而，当MRI脂肪分数与Folch值相关联时，这种相关性值更强，从而产生了预测肝脏甘油三酯浓度的新方程（甘油三酯mg /g肝组织= 5.082 +（432.104 *多回声MRI脂肪分数））。在另外31名患者（24名肥胖患者和7名对照患者）中验证了该公式，结果显示测量值和估计的Folch值之间存在强相关性。多变量分析表明，所调查的变量中没有一个能提高方程的Folch预测能力。通过MRI脂肪分数和Folch值，肥胖患者与对照组相比脂肪变性增加。减肥手术改善了肥胖患者术后一年的MRI脂肪分数值和Folch值。多回声MRI是一种准确的方法来确定肝脏脂质浓度，使用我们的新方程，代表了一种经济的非侵入性方法来诊断和监测人类脂肪变性。
Non-alcoholic fatty liver disease (NAFLD) is caused by abnormal accumulation of lipids within liver cells. Its prevalence is increasing in developed countries in association with obesity, and it represents a risk factor for non-alcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma. Since NAFLD is usually asymptomatic at diagnosis, new non-invasive approaches are needed to determine the hepatic lipid content in terms of diagnosis, treatment and control of disease progression. Here, we investigated the potential of magnetic resonance imaging (MRI) to quantitate and monitor the hepatic triglyceride concentration in humans. A prospective study of diagnostic accuracy was conducted among 129 consecutive adult patients (97 obesity and 32 non-obese) to compare multi-echo MRI fat fraction, grade of steatosis estimated by histopathology, and biochemical measurement of hepatic triglyceride concentration (that is, Folch value). MRI fat fraction positively correlates with the grade of steatosis estimated on a 0 to 3 scale by histopathology. However, this correlation value was stronger when MRI fat fraction was linked to the Folch value, resulting in a novel equation to predict the hepatic triglyceride concentration (mg of triglycerides/g of liver tissue = 5.082 + (432.104 * multi-echo MRI fat fraction)). Validation of this formula in 31 additional patients (24 obese and 7 controls) resulted in robust correlation between the measured and estimated Folch values. Multivariate analysis showed that none of the variables investigated improves the Folch prediction capacity of the equation. Obese patients show increased steatosis compared to controls using MRI fat fraction and Folch value. Bariatric surgery improved MRI fat fraction values and the Folch value estimated in obese patients one year after surgery. Multi-echo MRI is an accurate approach to determine the hepatic lipid concentration by using our novel equation, representing an economic non-invasive method to diagnose and monitor steatosis in humans.
登录
查看更多内容
影响因子：
7.6
作者：
Permutt Z;Le TA;Peterson MR;Seki E;Brenner DA;Sirlin C;Loomba R
通讯作者：
Loomba R
影响因子：
3.3
作者：
Marsman, H;Matsushita, T;Nyberg, SL
通讯作者：
Nyberg, SL
影响因子：
3.4
作者：
Zaitoun, AM;Al Mardini, H;Record, CO
通讯作者：
Record, CO
影响因子：
4.4
作者：
Guiu, Boris;Petit, Jean-Michel;Krause, Denis
通讯作者：
Krause, Denis
影响因子：
19.7
作者：
O'Regan, Declan P.;Callaghan, Martina F.;Schmitz, Stephan A.
通讯作者：
Schmitz, Stephan A.