Revisiting steroidogenesis and its role in immune regulation with the advanced tools and technologies.
Revisiting steroidogenesis and its role in immune regulation with the advanced tools and technologies.
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DOI：
10.1038/s41435-021-00139-3
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发表时间：
2021-07
影响因子：
5
通讯作者：
Mahata B
中科院分区：
文献类型：
--
作者：
Chakraborty S;Pramanik J;Mahata B
历史上，工具和技术促进了科学发现。类固醇激素研究也不例外。不幸的是，该领域的巨大进步使这一研究领域黯然失色，并将其标记为一个已解决的主题。然而，它应该是相反的。该地区应该以其坚实的基础闪闪发光，吸引下一代科学家。在过去的世纪里，人们发现了大量有关甾体激素的生物化学、分子生物学、细胞生物学、生理学和病理学方面的新事实。几项创新被用于挽救生命的治疗策略，如合成类固醇，类固醇合成和类固醇信号传导抑制剂。类固醇分子对细胞代谢、盐和水平衡、生殖系统的发育和功能、怀孕和免疫细胞功能表现出不同的影响。尽管有大量的研究，类固醇免疫调节作用的分子基础仍然是个谜。最近的兴奋局部腺体外类固醇激素在调节炎症和免疫是振兴的主题与一个新的视角。因此，本文综述了类固醇激素合成在炎症和免疫调节中的作用，讨论了尚未解决的问题，以及随着新工具和技术的发展以及科学方法的进步，这一领域将如何带来类固醇激素研究的另一个黄金时代。
Historically tools and technologies facilitated scientific discoveries. Steroid hormone research is not an exception. Unfortunately, the dramatic advancement of the field faded this research area and flagged it as a solved topic. However, it should have been the opposite. The area should glitter with its strong foundation and attract next-generation scientists. Over the past century, a myriad of new facts on biochemistry, molecular biology, cell biology, physiology and pathology of the steroid hormones was discovered. Several innovations were made and translated into life-saving treatment strategies such as synthetic steroids, and inhibitors of steroidogenesis and steroid signaling. Steroid molecules exhibit their diverse effects on cell metabolism, salt and water balance, development and function of the reproductive system, pregnancy, and immune-cell function. Despite vigorous research, the molecular basis of the immunomodulatory effect of steroids is still mysterious. The recent excitement on local extra-glandular steroidogenesis in regulating inflammation and immunity is revitalizing the topic with a new perspective. Therefore, here we review the role of steroidogenesis in regulating inflammation and immunity, discuss the unresolved questions, and how this area can bring another golden age of steroid hormone research with the development of new tools and technologies and advancement of the scientific methods.
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DOI：
10.1073/pnas.040577497
发表时间：
2000-03-14
影响因子：
11.1
作者：
Bynoe, MS;Grimaldi, CM;Diamond, B
通讯作者：
Diamond, B
影响因子：
8.8
作者：
Boor, P. P. C.;Metselaar, H. J.;Kwekkeboom, J.
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Kwekkeboom, J.
影响因子：
56.9
作者：
Anderson, MS;Venanzi, ES;Mathis, D
通讯作者：
Mathis, D
影响因子：
8.6
作者：
Boks, Martine A.;Kager-Groenland, Judith R.;ten Brinke, Anja
通讯作者：
ten Brinke, Anja
影响因子：
4.6
作者：
CUTOLO, M;ACCARDO, S;CASTAGNETTA, L
通讯作者：
CASTAGNETTA, L