Healing, antioxidant and cytoprotective properties of Indigofera truxillensis in different models of gastric ulcer in rats.
Healing, antioxidant and cytoprotective properties of Indigofera truxillensis in different models of gastric ulcer in rats.
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DOI：
10.3390/ijms131114973
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发表时间：
2012-11-15
影响因子：
5.6
通讯作者：
Souza-Brito AR
中科院分区：
文献类型：
--
作者：
Luiz-Ferreira A;Cola M;Barbastefano V;de-Faria FM;Almeida AB;Farias-Silva E;Calvo TR;Hiruma-Lima CA;Vilegas W;Souza-Brito AR
本研究评价了木蓝叶水溶性组分（AqF 100 mg/kg）和乙酸乙酯组分（AcF 50 mg/kg）的抗溃疡活性及其机制。选择该剂量以评估其对溃疡愈合的活性及其对胃酸和粘液分泌、前列腺素产生和抗氧化酶活性（超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）和谷胱甘肽还原酶（GSH-Rd））的作用。用无水乙醇诱发胃溃疡。抗分泌作用，粘液和前列腺素的生产，愈合和抗氧化酶的活性进行了评价。AqF和AcF对乙醇所致的胃粘膜损伤有明显的抑制作用。与溶剂相比，100和50 mg/kg剂量组的该效应具有统计学显著性。这两种组分均不干扰胃分泌。AcF增加了PGE 2的产生，两种组分都增加了粘液的产生。L-NAME不改变各组分的胃保护作用，但N-乙基马来酰亚胺仅减弱AcF。在缺血/再灌注模型中，两种组分均抑制粘膜损伤。AcF能提高SOD、GSH-Px和GSH-Rd活性，而AqF仅能提高SOD和GSH-Px活性。在乙酸诱导的溃疡模型中，AcF仅加速溃疡愈合。这些结果表明，木蓝具有胃保护作用，刺激保护因子和抗氧化酶。
The present study evaluated the antiulcerogenic activity and mechanisms of the aqueous (AqF 100 mg/kg) and ethyl acetate (AcF 50 mg/kg) fractions from Indigofera truxillensis leaves. This dose was selected to assess its activity on ulcer healing and its action on gastric acid and mucus secretion, prostaglandin production and antioxidant enzyme activity (superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and glutathione reductase (GSH-Rd)). Gastric ulcer was induced by absolute ethanol. Antisecretory action, mucus and prostaglandin production, healing and antioxidant enzyme activities were evaluated for both fractions. AqF and AcF significantly inhibited the gastric mucosal damage caused by ethanol. This effect was statistically significant at 100 and 50 mg/kg compared with the vehicle. Neither fraction interfered with gastric secretion. AcF increased the PGE2 production, and both fractions increased mucus production. l-NAME did not alter the gastroprotection exerted by the fractions, but N-ethylmaleimide attenuated only AcF. In the ischemia/reperfusion model both fractions inhibited the mucosal damage. AcF increased SOD, GSH-Px and GSH-Rd activity, but AqF increased only SOD and GSH-Px. In the acetic acid-induced ulcer model AcF only accelerated ulcer healing. These results showed that Indigofera truxillensis acted as a gastroprotective agent, stimulating protective factors and antioxidants enzymes.
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影响因子：
2.5
作者：
deFoneska, Arushi;Kaunitz, Jonathan D.
通讯作者：
Kaunitz, Jonathan D.
影响因子：
2.7
作者：
Arrieta, J;Benitez, J;Navarrete, A
通讯作者：
Navarrete, A
DOI：
10.1093/ecam/nep123
发表时间：
2011
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Calvo TR;Cardoso CR;da Silva Moura AC;Dos Santos LC;Colus IM;Vilegas W;Varanda EA
通讯作者：
Varanda EA
影响因子：
29.4
作者：
KONTUREK, PK;BRZOZOWSKI, T;DEMBINSKI, A
通讯作者：
DEMBINSKI, A
影响因子：
3.8
作者：
Kimura, M;Goto, S;Kondo, T
通讯作者：
Kondo, T