Maternal-Fetal Inflammation in the Placenta and the Developmental Origins of Health and Disease.
Maternal-Fetal Inflammation in the Placenta and the Developmental Origins of Health and Disease.
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DOI：
10.3389/fimmu.2020.531543
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发表时间：
2020
影响因子：
7.3
通讯作者：
Gernand AD
中科院分区：
文献类型：
--
作者：
Goldstein JA;Gallagher K;Beck C;Kumar R;Gernand AD
胎儿生命中的事件影响长期健康结果。胎盘是第一个形成的器官，是母体和胎儿循环并置的部位。大多数妊娠疾病都是由胎盘引起的，影响或反映在胎盘中。这篇综述的目的是描述胎盘中的主要炎症过程，讨论它们的免疫学，并将它们与短期和长期疾病联系起来。急性胎盘炎症（API），包括母体和胎儿的炎症反应，对应于绒毛膜炎的临床诊断，并与呼吸和神经发育疾病相关。慢性胎盘炎性病变（CPI）包括病因不明的慢性绒毛炎、慢性蜕膜炎、慢性绒毛膜炎、嗜酸性T细胞血管炎和慢性组织细胞绒毛间炎。这些疾病的研究较少，但具有复杂的免疫学，并显示对胎儿免疫系统的机械影响。总的来说，在描述胎盘炎症对后代健康的长期影响方面还有很多工作要做。
Events in fetal life impact long-term health outcomes. The placenta is the first organ to form and is the site of juxtaposition between the maternal and fetal circulations. Most diseases of pregnancy are caused by, impact, or are reflected in the placenta. The purpose of this review is to describe the main inflammatory processes in the placenta, discuss their immunology, and relate their short- and long-term disease associations. Acute placental inflammation (API), including maternal and fetal inflammatory responses corresponds to the clinical diagnosis of chorioamnionitis and is associated with respiratory and neurodevelopmental diseases. The chronic placental inflammatory pathologies (CPI), include chronic villitis of unknown etiology, chronic deciduitis, chronic chorionitis, eosinophilic T-cell vasculitis, and chronic histiocytic intervillositis. These diseases are less-well studied, but have complex immunology and show mechanistic impacts on the fetal immune system. Overall, much work remains to be done in describing the long-term impacts of placental inflammation on offspring health.
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