Noninvasive Activation Imaging of Ventricular Arrhythmias by Spatial Gradient Sparse in Frequency Domain-Application to Mapping Reentrant Ventricular Tachycardia.
Noninvasive Activation Imaging of Ventricular Arrhythmias by Spatial Gradient Sparse in Frequency Domain-Application to Mapping Reentrant Ventricular Tachycardia.
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DOI：
10.1109/tmi.2018.2866951
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发表时间：
2019-03
影响因子：
10.6
通讯作者：
He B
中科院分区：
文献类型：
--
作者：
Yang T;Pogwizd SM;Walcott GP;Yu L;He B
本研究的目的是开发和评估一种新的成像方法（SSF，空间梯度稀疏频域）的无创体表电位图（BSPM）测量室性心律失常的激活序列重建。我们制定和解决的心电图逆问题在频域中，和激活时间编码的相位信息的成像解决方案。细胞自动机心脏模型用于产生局灶性室性心动过速（VT）。添加不同水平的高斯白色噪声来模拟噪声污染的BSPM。将SSF与加权最小范数（WMN）逆解的性能进行了比较.我们还在猪模型中评估了该方法，同时进行心内和体表记录。在由左前降支动脉闭塞产生的心肌梗死猪中观察到4例折返性VT。将折返性室性心动过速的激动序列与心内单极电图的激动序列进行比较。在局灶性室性心动过速模拟中，在不同噪声水平下，SSF使相关系数（CC）平均提高5%，定位误差（LE）平均降低2.7mm。在折返性室性心动过速的动物验证中，SSF在定位折返回路中最早和最晚激动部位方面的平均CC为88%，平均LE为6.3 mm。我们有希望的结果表明，SSF提供了无创成像能力的检测和映射大折返电路在三维心室空间。SSF可能成为识别和定位局灶性和折返性室性心动过速消融潜在靶点的有用成像工具。
The aim of this study is to develop and evaluate a novel imaging method (SSF, Spatial gradient Sparse in Frequency domain) for the reconstruction of activation sequences of ventricular arrhythmia from noninvasive body surface potential map (BSPM) measurements. We formulated and solved the electrocardiographic inverse problem in the frequency domain, and the activation time was encoded in the phase information of the imaging solution. A cellular automaton heart model was used to generate focal ventricular tachycardia (VT). Different levels of Gaussian white noise were added to simulate noisecontaminated BSPM. The performance of SSF was compared with that of WMN (weighted minimum norm) inverse solution. We also evaluated the method in a swine model with simultaneous intracardiac and body surface recordings. Four reentrant VTs were observed in pigs with myocardial infarction generated by left anterior descending artery occlusion. The imaged activation sequences of reentrant VTs were compared with those obtained from intracardiac unipolar electrograms. In focal VT simulation, SSF increased the correlation coefficient (CC) by 5% and decreased localization errors (LEs) by 2.7 mm on average under different noise levels. In the animal validation with reentrant VT, SSF achieved an average CC of 88% and an average LE of 6.3 mm in localizing the earliest and latest activation site in the reentry circuit. Our promising results suggest SSF provides noninvasive imaging capability of detecting and mapping macroreentrant circuits in 3-dimensional ventricular space. SSF may become a useful imaging tool of identifying and localizing the potential targets for ablation of focal and reentrant ventricular tachycardia.
影响因子：
5.5
作者：
Han, Chengzong;Pogwizd, Steven M.;Killingsworth, Cheryl R.;Zhou, Zhaoye;He, Bin
通讯作者：
He, Bin