Noninvasive cardiac activation imaging of ventricular arrhythmias during drug-induced QT prolongation in the rabbit heart.
Noninvasive cardiac activation imaging of ventricular arrhythmias during drug-induced QT prolongation in the rabbit heart.
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DOI：
10.1016/j.hrthm.2013.06.010
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发表时间：
2013-10
期刊：
影响因子：
5.5
通讯作者：
He, Bin
中科院分区：
文献类型：
--
作者：
Han, Chengzong;Pogwizd, Steven M.;Killingsworth, Cheryl R.;Zhou, Zhaoye;He, Bin
关键词：
通过非侵入性体表电位成像心肌激活有望为心血管研究和临床医学提供帮助。本研究旨在探讨无创性三维心脏电成像(3DCEI)技术在药物性QT延长过程中对动态变化的室性心律失常激活模式的表征能力。8只兔在闭胸状态下同时进行体表电位标测和三维心内标测。对静脉注射过程中诱发的室性早搏、联结和尖端扭矩(TDP)进行数据分析。以不同输液速率的组合给予氯硝铵和苯肾上腺素。首次给药周期QT间期显著延长(175±7ms至274±31ms)，校正QT间期显著延长(183±5ms至262±21ms)。所有异位搏动都是由焦点激活模式启动的。TDPs的起搏发生在焦点部位，而随后的搏动是由于不同部位或两个相互竞争的焦点部位的焦点活动所致。成像结果捕捉到了激活模式的动态变化，与同步测量结果具有很好的相关性，相关系数为0.65±0.02，平均为111次异位搏动。初始激活部位定位在~5 mm。3DCEI技术可以定位环磷酰胺和苯肾上腺素引起的兔QT延长过程中TdP的激活来源和图像激活序列。它为非侵入性地研究药物输注的致心律失常效应和在逐个心跳的基础上评估心律失常的机制提供了可能性。
Imaging myocardial activation from noninvasive body surface potentials promises to aid in both cardiovascular research and clinical medicine. This study investigates the ability of a noninvasive 3-dimensional cardiac electrical imaging (3DCEI) technique for characterizing the activation patterns of dynamically changing ventricular arrhythmias during drug-induced QT prolongation in rabbit. Simultaneous body surface potential mapping and 3-dimensional intra-cardiac mapping were performed in a closed-chest condition in eight rabbits. Data analysis was performed on premature ventricular complexes, couplets, and torsades de pointes (TdP) induced during i.v. administration of clofilium and phenylephrine with combinations of various infusion rates. The drug infusion led to significant increase of QT interval (175±7ms to 274±31ms) and rate-corrected QT interval (183±5ms to 262±21ms) during the first dose cycle. All the ectopic beats initiated by a focal activation pattern. The initial beat of TdPs arose at focal site, whereas the subsequent beats were due to focal activity from different sites or two competing focal sites. The imaged results captured the dynamic shift of activation patterns and were in good correlation with the simultaneous measurements with a correlation coefficient of 0.65±0.02 averaged over 111 ectopic beats. Sites of initial activation were localized to be ~5mm. The 3DCEI technique could localize the origin of activation and image activation sequence of TdP during QT prolongation induced by clofilium and phenylephrine in rabbit. It offers the potential to non-invasively investigate the proarrhythmic effects of drug infusion and assess the mechanisms of arrhythmias on a beat-to-beat basis.
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影响因子：
4.6
作者：
BARR, RC;RAMSEY, M;SPACH, MS
通讯作者：
SPACH, MS
影响因子：
3.8
作者：
Armoundas, AA;Feldman, AB;Cohen, RJ
通讯作者：
Cohen, RJ
DOI：
10.1016/s0735-1097(96)00588-8
发表时间：
1997-03-15
影响因子：
24
作者：
Asano, Y;Davidenko, JM;Jalife, J
通讯作者：
Jalife, J
影响因子：
3.7
作者：
Berger, Thomas;Pfeifer, Bernhard;Seger, Michael
通讯作者：
Seger, Michael
影响因子：
20.1
作者：
MILLER, WT;GESELOWITZ, DB
通讯作者：
GESELOWITZ, DB