Integration of BOLD-fMRI and DTI into radiation treatment planning for high-grade gliomas located near the primary motor cortexes and corticospinal tracts.
Integration of BOLD-fMRI and DTI into radiation treatment planning for high-grade gliomas located near the primary motor cortexes and corticospinal tracts.
复制标题
将 BOLD-fMRI 和 DTI 整合到初级运动皮层和皮质脊髓束附近的高级神经胶质瘤的放射治疗计划中。
DOI：
10.1186/s13014-015-0364-1
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发表时间：
2015-03-08
期刊：
影响因子：
--
通讯作者：
Xie Y
中科院分区：
文献类型：
--
作者：
Wang M;Ma H;Wang X;Guo Y;Xia X;Xia H;Guo Y;Huang X;He H;Jia X;Xie Y
本研究的主要目的是评估将血氧水平依赖性功能磁共振成像 (BOLD-fMRI) 和扩散张量成像 (DTI) 数据整合到初级运动皮层 (PMC) 和皮质脊髓束 (CST) 附近的高级别胶质瘤放射治疗计划中的效果。 2012 年至 2014 年间，总共招募了 20 名患有 PMC 和 CST 附近高级别胶质瘤的患者。双侧PMC和CST均位于正常区域，与病灶靶区无重叠。根治性放疗前对患者（卡诺夫斯基评分 ≥ 70）进行BOLD-fMRI、DTI和常规MRI检查。对每位患者进行四项不同的影像学研究：计划计算机断层扫描 (CT)、解剖 MRI、DTI 和 BOLD-fMRI。对于每个病例，三位不同的物理学家使用 Pinnacle 计划系统制定了三种治疗计划（3DCRT、IMRT 和 IMRT_PMC&CST）。我们的研究表明，3DCRT 和 IMRT 计划在剂量均匀性方面没有显着差异，但 IMRT 显示出更好的计划靶体积 (PTV) 剂量一致性。此外，我们发现 IMRT_PMC&CST 组同侧和对侧 PMC 和 CST 区域的 Dmax 和 Dmean 显着降低 (p<0.001)。总之，将 BOLD-fMRI 和 DTI 整合到放射治疗计划中是可行且有益的。在上述技术的帮助下，与目标体积相邻的双侧 PMC 和 CST 可以被清楚地标记为 OAR，并在治疗过程中幸免。
The main objective of this study was to evaluate the efficacy of integrating the blood oxygen level dependent functional magnetic resonance imaging (BOLD-fMRI) and diffusion tensor imaging (DTI) data into radiation treatment planning for high-grade gliomas located near the primary motor cortexes (PMCs) and corticospinal tracts (CSTs). A total of 20 patients with high-grade gliomas adjacent to PMCs and CSTs between 2012 and 2014 were recruited. The bilateral PMCs and CSTs were located in the normal regions without any overlapping with target volume of the lesions. BOLD-fMRI, DTI and conventional MRI were performed on patients (Karnofsky performance score ≥ 70) before radical radiotherapy treatment. Four different imaging studies were conducted in each patient: a planning computed tomography (CT), an anatomical MRI, a DTI and a BOLD-fMRI. For each case, three treatment plans (3DCRT, IMRT and IMRT_PMC&CST) were developed by 3 different physicists using the Pinnacle planning system. Our study has shown that there was no significant difference between the 3DCRT and IMRT plans in terms of dose homogeneity, but IMRT displayed better planning target volume (PTV) dose conformity. In addition, we have found that the Dmax and Dmean to the ipsilateral and contralateral PMC and CST regions were considerably decreased in IMRT_PMC&CST group (p < 0.001). In conclusion, integration of BOLD-fMRI and DTI into radiation treatment planning is feasible and beneficial. With the assistance of the above-described techniques, the bilateral PMCs and CSTs adjacent to the target volume could be clearly marked as OARs and spared during treatment.
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DOI：
10.1016/0360-3016(94)00550-8
发表时间：
1995-02-15
影响因子：
7
作者：
ROMAN, DD;SPERDUTO, PW
通讯作者：
SPERDUTO, PW
DOI：
10.1016/j.ijrobp.2009.10.064
发表时间：
2010-09-01
影响因子：
7
作者：
Pantelis, Evaggelos;Papadakis, Nikolaos;Salvaras, Nikolaos
通讯作者：
Salvaras, Nikolaos
影响因子：
8.8
作者：
BLEEHEN, NM;STENNING, SP
通讯作者：
STENNING, SP
DOI：
10.1016/s0360-3016(99)00513-1
发表时间：
2000-03-15
影响因子：
7
作者：
Flickinger, JC;Kondziolka, D;Pollock, B
通讯作者：
Pollock, B
影响因子：
3.6
作者：
Arbea, Leire;Isaac Ramos, Luis;Aristu, Javier
通讯作者：
Aristu, Javier