Crosstalk between cancer cells and blood endothelial and lymphatic endothelial cells in tumour and organ microenvironment.
Crosstalk between cancer cells and blood endothelial and lymphatic endothelial cells in tumour and organ microenvironment.
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DOI：
10.1017/erm.2015.2
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发表时间：
2015-01-30
影响因子：
6.2
通讯作者：
Popel AS
中科院分区：
文献类型：
--
作者：
Lee E;Pandey NB;Popel AS
肿瘤和器官微环境对于癌症进展和转移至关重要。微环境中的多种非恶性细胞类型与癌细胞之间的串扰促进肿瘤生长和转移。血液和淋巴管内皮细胞（BEC和LEC）是微环境中的两个组成部分。肿瘤血管（BV），包括BEC，作为血液供应到肿瘤的管道，是重要的肿瘤生长以及血源性肿瘤传播。淋巴管（LV）包括LEC，与BV相比相对渗漏，对于淋巴源性肿瘤传播至关重要。除了描述BV和LV的传统作用外，我们还讨论了这些内皮细胞的新出现的作用：它们通过BEC和LEC分泌的分子（也称为血管分泌因子和淋巴管分泌因子）与癌细胞的串扰。这篇综述表明，BEC和LEC在各种微环境中可以协调肿瘤的进展，并提出了新的机制为基础的策略，以发现新的治疗方法，以补充传统的抗血管生成和抗淋巴管生成疗法。
Tumour and organ microenvironments are crucial for cancer progression and metastasis. Crosstalk between multiple non-malignant cell types in the microenvironments and cancer cells promotes tumour growth and metastasis. Blood and lymphatic endothelial cells (BEC and LEC) are two of the components in the microenvironments. Tumour blood vessels (BV), comprising BEC, serve as conduits for blood supply into the tumour, and are important for tumour growth as well as haematogenous tumour dissemination. Lymphatic vessels (LV), comprising LEC, which are relatively leaky compared with BV, are essential for lymphogenous tumour dissemination. In addition to describing the conventional roles of the BV and LV, we also discuss newly emerging roles of these endothelial cells: their crosstalk with cancer cells via molecules secreted by the BEC and LEC (also called angiocrine and lymphangiocrine factors). This review suggests that BEC and LEC in various microenvironments can be orchestrators of tumour progression and proposes new mechanism-based strategies to discover new therapies to supplement conventional anti-angiogenic and anti-lymphangiogenic therapies.
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影响因子：
11.2
作者：
Brantley-Sieders DM;Dunaway CM;Rao M;Short S;Hwang Y;Gao Y;Li D;Jiang A;Shyr Y;Wu JY;Chen J
通讯作者：
Chen J
影响因子：
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通讯作者：
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影响因子：
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影响因子：
120.7
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通讯作者：
Hunt, Kelly K.
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50.3
作者：
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