Update on management of diabetic foot ulcers.
Update on management of diabetic foot ulcers.
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DOI：
10.1111/nyas.13569
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发表时间：
2018-01
影响因子：
5.2
通讯作者：
Mathioudakis N
中科院分区：
文献类型：
--
作者：
Everett E;Mathioudakis N
糖尿病足溃疡（DFU）是糖尿病的一种严重并发症，可导致显着的发病率和死亡率。前 12 个月内与 DFU 相关的死亡率估计为 5%，5 年死亡率估计为 42%。 DFU 管理的标准做法包括手术清创、敷料以促进湿润的伤口环境和渗出物控制、伤口卸载、血管评估以及感染和血糖控制。这些做法最好由多学科糖尿病足伤口诊所协调。即使采用这种综合方法，DFU 的结果仍有改进的空间。已经研究了几种辅助疗法来减少 DFU 愈合时间和截肢率。我们回顾了当前护理实践标准的基本原理和指南，并回顾了辅助药物功效的证据。审查的辅助疗法包括以下类别：非手术清创剂、敷料和局部制剂、氧疗法、负压伤口疗法、无细胞生物产品、人类生长因子、能量疗法和全身疗法。尽管大部分数据是具有高偏倚风险的小型随机对照试验，但许多这些药物被发现有助于提高伤口愈合率。
Diabetic foot ulcers (DFUs) are a serious complication of diabetes that results in significant morbidity and mortality. Mortality rates associated with development of a DFU are estimated to be 5% in the first 12 months, and 5-year morality rates have been estimated at 42%. The standard practices in DFU management include surgical debridement, dressings to facilitate a moist wound environment and exudate control, wound off-loading, vascular assessment, and infection and glycemic control. These practices are best coordinated by a multidisciplinary diabetic foot wound clinic. Even with this comprehensive approach, there is there is still room for improvement in DFU outcomes. Several adjuvant therapies have been studied to reduce DFU healing times and amputation rates. We reviewed the rationale and guidelines for current standard of care practices and reviewed the evidence for the efficacy of adjuvant agents. The adjuvant therapies reviewed include the following categories: non-surgical debridement agents, dressings and topical agents, oxygen therapies, negative pressure wound therapy, acellular bioproducts, human growth factors, energy based therapies, and systemic therapies. Many of these agents have been found to be beneficial in improving wound healing rates, although a large proportion of the data are small randomized controlled trials with high risks of bias.
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影响因子：
2.9
作者：
Braun, Liza;Kim, Paul J.;Lavery, Lawrence A.
通讯作者：
Lavery, Lawrence A.
影响因子：
4.3
作者：
Driver, Vickie R.;Fabbi, Matteo;Gibbons, Gary
通讯作者：
Gibbons, Gary
影响因子：
6.5
作者：
Christman, Andrea L.;Selvin, Elizabeth;Margolis, David J.;Lazarus, Gerald S.;Garza, Luis A.
通讯作者：
Garza, Luis A.
影响因子：
0.7
作者：
Armstrong, DG;Short, B;Boulton, AJM
通讯作者：
Boulton, AJM
DOI：
10.12968/bjon.2016.25.12.s59
发表时间：
2016-06-23
期刊：
British journal of nursing (Mark Allen Publishing)
影响因子：
--
作者：
Dawn Hunt, Sharon;Haycocks, Samantha;Guttormsen, Karl
通讯作者：
Guttormsen, Karl