The Human Connectome Project: a data acquisition perspective.

The Human Connectome Project: a data acquisition perspective.
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DOI:
10.1016/j.neuroimage.2012.02.018
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发表时间:
2012-10-01
期刊:
影响因子:
5.7
通讯作者:
Yacoub, E.
Yacoub, E.
中科院分区:
医学1区
文献类型:
--
作者:
Van Essen, D. C.;Ugurbil, K.;Auerbach, E.;Barch, D.;Behrens, T. E. J.;Bucholz, R.;Chang, A.;Chen, L.;Corbetta, M.;Curtiss, S. W.;Della Penna, S.;Feinberg, D.;Glasser, M. F.;Harel, N.;Heath, A. C.;Larson-Prior, L.;Marcus, D.;Michalareas, G.;Moeller, S.;Oostenveld, R.;Petersen, S. E.;Prior, F.;Schlaggar, B. L.;Smith, S. M.;Snyder, A. Z.;Xu, J.;Yacoub, E.

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人类连接组计划(HCP)是一项雄心勃勃的5年努力,旨在表征健康成年人的大脑连接和功能及其变异性。这篇综述总结了一个由HCP研究人员组成的联盟正在实施的数据获取计划,他们将使用多种成像方式以及广泛的行为和遗传数据研究1200名受试者(双胞胎和他们的非双胞胎兄弟姐妹)。成像方式将包括扩散成像(DMRI)、静息功能磁共振(R-fMRI)、任务诱发功能磁共振(T-fMRI)、结构和髓鞘定位的T1和T2加权MRI,以及脑磁图和脑电图术(MEG/EEG)。鉴于获得尽可能最佳数据质量的重要性,我们讨论了在拨款的头两年(第一阶段)为改进和优化HCP数据采集的许多方面所做的努力,包括新的7T扫描仪、定制的3T扫描仪和改进的MR脉冲序列。
The Human Connectome Project (HCP) is an ambitious 5-year effort to characterize brain connectivity and function and their variability in healthy adults. This review summarizes the data acquisition plans being implemented by a consortium of HCP investigators who will study a population of 1200 subjects (twins and their non-twin siblings) using multiple imaging modalities along with extensive behavioral and genetic data. The imaging modalities will include diffusion imaging (dMRI), resting-state fMRI (R-fMRI), task-evoked fMRI (T-fMRI), T1- and T2-weighted MRI for structural and myelin mapping, plus combined magnetoencephalography and electroencephalography (MEG/EEG). Given the importance of obtaining the best possible data quality, we discuss the efforts underway during the first two years of the grant (Phase I) to refine and optimize many aspects of HCP data acquisition, including a new 7T scanner, a customized 3T scanner, and improved MR pulse sequences.
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