Normal glucocorticoid fast feedback following chronic 50% corticosterone pellet treatment.
Normal glucocorticoid fast feedback following chronic 50% corticosterone pellet treatment.
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正常%20糖皮质激素%20快速%20反馈%20以下%20慢性%2050%%20皮质酮%20颗粒%20治疗。
DOI：
10.1016/0306-4530(95)00012-7
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发表时间：
1995
影响因子：
3.7
通讯作者：
Young,EA
中科院分区：
文献类型：
--
作者：
Young,EA
Dallman和Jones首先证明了糖皮质激素对促肾上腺皮质激素(ACTH)分泌的快速影响。糖皮质激素的快速反馈被认为依赖于大脑反馈部位，特别是海马体。目前的研究是检验海马体肾上腺类固醇受体变化和快速反馈变化之间联系的一系列研究的一部分。我们以前的研究已经证明，慢性应激和慢性皮质酮注射能够减弱注射糖皮质激素对ACTH分泌的快速反馈效应。目前的研究探索了给予不同形式的外源性皮质酮，50%皮质酮颗粒，这种治疗导致皮质酮水平稳定在7-8μg/dl，是否能够影响快速反馈。大鼠分别在植入50%皮质酮微丸前后进行研究。在束缚应激开始时给予皮质醇，在皮质酮小丸植入前的上午和下午，ACTH的释放都在30min内减少。植入50%皮质酮后，ACTH应激反应在上午和下午均减弱。然而，在束缚应激开始时注射皮质醇继续对ACTH的分泌产生快速反馈作用。这些研究表明，持续较低的血浆皮质酮浓度为6-7μg/dl能够抑制整体应激反应，但不能对快速反馈做出反应。这与我们之前的皮质酮注射范例的研究不同，皮质酮注射范例会在糖皮质激素快速反馈中产生异常。
Rapid effects of glucocorticoids on adrenocorticotropin hormone (ACTH) secretion were first demonstrated by Dallman and Jones. Glucocorticoid fast feedback is believed to be dependent upon brain feedback sites, particularly the hippocampus. The current studies are part of a series of studies examining the links between hippocampal adrenal steroid receptor changes and changes in fast feedback. Our previous studies have demonstrated that chronic stress and chronic corticosterone injections are capable of diminishing the fast feedback effect of injected glucocorticoids on ACTH secretion. The current studies explore whether administration of a different form of exogenous corticosterone, a 50% corticosterone pellet, a treatment that leads to constant corticosterone levels of 7–8 μg/dl, was capable of affecting fast feedback. Rats were studied both before and after the implantation of the 50% corticosterone pellets. Administration of cortisol at the initiation of restraint stress resulted in decreased ACTH release over the course of 30 min in both the morning and afternoon before implantation of corticosterone pellets. Following the implantation of 50% corticosterone pellets, the overall ACTH stress response was diminished in both the morning and the afternoon. However, cortisol injection at the initiation of restraint stress continued to exert fast feedback effects on ACTH secretion. These studies suggest that constant low plasma corticosterone concentrations of 6–7 μg/dl are able to inhibit the overall stress response but not the ability to respond to fast feedback. This contrasts with our previous studies with a corticosterone injection paradigm which produced abnormalities in glucocorticoid fast feedback.
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影响因子：
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作者：
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DOI：
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发表时间：
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发表时间：
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影响因子：
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作者：
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