Placodal sensory ganglia coordinate the formation of the cranial visceral motor pathway.
Placodal sensory ganglia coordinate the formation of the cranial visceral motor pathway.
复制标题
DOI：
10.1002/dvdy.22273
复制
发表时间：
2010-04
影响因子：
2.5
通讯作者：
Gaufo, Gary O.
中科院分区：
文献类型：
--
作者：
Takano-Maruyama, Masumi;Chen, Yiju;Gaufo, Gary O.
关键词：
The parasympathetic reflex circuit is controlled by three basic neurons. In the vertebrate head, the sensory, pre- and post-ganglionic neurons that comprise each circuit have stereotypic positions along the anteroposterior (AP) axis, suggesting that the circuit arises from a common developmental plan. Here we show that precursors of the VIIth circuit are initially aligned along the AP axis, where the placode-derived sensory neurons provide a critical “guidepost” through which preganglionic axons and their neural crest-derived postganglionic targets navigate prior to reaching their distant target sites. In the absence of the placodal sensory ganglion, preganglionic axons terminate and the neural crest fated for postganglionic neurons undergo apoptosis at the site normally occupied by the placodal sensory ganglion. The stereotypic organization of the parasympathetic cranial sensory-motor circuit thus emerges from the initial alignment of its precursors along the AP axis, with the placodal sensory ganglion coordinating the formation of the motor pathway.
登录
查看更多内容
影响因子：
10.5
作者：
Arenkiel, BR;Tvrdik, P;Capecchi, MR
通讯作者：
Capecchi, MR
影响因子：
3.5
作者：
Jacob, J;Tiveron, MC;Guthrie, S
通讯作者：
Guthrie, S
影响因子：
16.2
作者：
Farago, AF;Awatramani, RB;Dymecki, SM
通讯作者：
Dymecki, SM
影响因子：
10.5
作者：
Keller, C;Hansen, MS;Capecchi, MR
通讯作者：
Capecchi, MR
影响因子：
4.6
作者：
Dauger, S;Pattyn, A;Brunet, JF
通讯作者：
Brunet, JF