Cancer survivorship, excess body fatness and weight-loss intervention-where are we in 2020?
Cancer survivorship, excess body fatness and weight-loss intervention-where are we in 2020?
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癌症存活率，过度肥胖和减肥干预-我们在2020年在哪里？
DOI：
10.1038/s41416-020-01155-2
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发表时间：
2021-03
影响因子：
8.8
通讯作者：
UK NIHR Cancer and Nutrition Collaboration (Population Health Stream)
中科院分区：
文献类型：
--
作者：
Anderson AS;Martin RM;Renehan AG;Cade J;Copson ER;Cross AJ;Grimmett C;Keaver L;King A;Riboli E;Shaw C;Saxton JM;UK NIHR Cancer and Nutrition Collaboration (Population Health Stream)
更早的诊断和更有效的治疗意味着，到2030年，英国癌症幸存者的估计人数预计将达到400万。然而，人们越来越认识到，过量的体脂(EBF)可能会影响癌症存活期和无病存活率的质量。几十年来，关于癌症患者体重管理的讨论一直被对无意减肥、低体重和增加体重的干预措施的担忧所主导，肥胖悖论的存在往往再次强化了这一担忧。肥胖悖论表明，高体重与某些类型癌症的生存益处有关。然而，观察证据为检验这一假设提供了强有力的依据，即在超重和肥胖的癌症幸存者中，促进体脂故意减少和保持骨骼肌的干预措施将在生存结果和对治疗相关副作用的长期影响方面带来重要的健康益处。在这篇文章中，我们概述了研究的必要性，以提高我们对减肥干预措施的健康益处的理解，例如结合体力活动的低卡路里健康饮食计划。特别是，迫切需要务实设计的复杂干预试验来开发有效的、临床实用的、以证据为基础的策略，以减少EBF并优化与常见癌症患者及其他癌症患者的身体成分。
Earlier diagnosis and more effective treatments mean that the estimated number of cancer survivors in the United Kingdom is expected to reach 4 million by 2030. However, there is an increasing realisation that excess body fatness (EBF) is likely to influence the quality of cancer survivorship and disease-free survival. For decades, the discussion of weight management in patients with cancer has been dominated by concerns about unintentional weight loss, low body weight and interventions to increase weight, often re-enforced by the existence of the obesity paradox, which indicates that high body weight is associated with survival benefits for some types of cancer. However, observational evidence provides strong grounds for testing the hypothesis that interventions for promoting intentional loss of body fat and maintaining skeletal muscle in overweight and obese cancer survivors would bring important health benefits in terms of survival outcomes and long-term impact on treatment-related side effects. In this paper, we outline the need for studies to improve our understanding of the health benefits of weight-loss interventions, such as hypocaloric healthy-eating plans combined with physical activity. In particular, complex intervention trials that are pragmatically designed are urgently needed to develop effective, clinically practical, evidence-based strategies for reducing EBF and optimising body composition in people living with and beyond common cancers.
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DOI：
10.1093/annonc/mdu042
发表时间：
2014-10
期刊：
Annals of oncology : official journal of the European Society for Medical Oncology
影响因子：
--
作者：
Chan DSM;Vieira AR;Aune D;Bandera EV;Greenwood DC;McTiernan A;Navarro Rosenblatt D;Thune I;Vieira R;Norat T
通讯作者：
Norat T
影响因子：
6.3
作者：
Arends, Jann;Bachmann, Patrick;Preiser, Jean-Charles
通讯作者：
Preiser, Jean-Charles
影响因子：
45.3
作者：
Harrigan, Maura;Cartmel, Brenda;Irwin, Melinda L.
通讯作者：
Irwin, Melinda L.
影响因子：
4.7
作者：
Doerstling SS;O'Flanagan CH;Hursting SD
通讯作者：
Hursting SD
影响因子：
28.4
作者：
Caan, Bette J.;Feliciano, Elizabeth M. Cespedes;Chen, Wendy Y.
通讯作者：
Chen, Wendy Y.