Examining Prenatal Dietary Factors in Association with Child Autism-Related Traits Using a Bayesian Mixture Approach: Results from 2 United States Cohorts.
Examining Prenatal Dietary Factors in Association with Child Autism-Related Traits Using a Bayesian Mixture Approach: Results from 2 United States Cohorts.
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DOI：
10.1016/j.cdnut.2023.101978
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发表时间：
2023-08
影响因子：
4.8
通讯作者：
Newschaffer, Craig J
中科院分区：
文献类型：
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作者：
Lyall, Kristen;Rando, Juliette;Wang, Siwen;Hamra, Ghassan B;Chavarro, Jorge;Weisskopf, Marc G;Croen, Lisa A;Fallin, M Daniele;Hertz-Picciotto, Irva;Volk, Heather E;Schmidt, Rebecca J;Newschaffer, Craig J
先前的研究表明，产前摄入某些营养物质与自闭症之间存在关系。我们使用贝叶斯建模方法检查了一套广泛的产前营养和食物。参与者来自早期自闭症风险纵向调查（n = 127），这是一个跟踪有自闭症孩子的妇女的队列，直到后来怀孕。参与者还从护士健康研究II （NHSII, n = 713）中抽取，这是一个美国女护士队列，用于比较分析。在这两项研究中，前瞻性报告的产前饮食信息来自食物频率问卷，并通过社会反应量表（SRS）测量儿童自闭症相关特征。贝叶斯核机回归用于检查几种与神经发育相关的营养物质的综合影响，包括多不饱和脂肪酸（PUFAs）、铁、锌、维生素D、叶酸和其他甲基供体，以及单独的这些主要食物来源，在原始和调整模型中与儿童SRS评分相关。在调整分析中，没有观察到早期自闭症风险纵向调查中的营养物质和两个队列中的食物对SRS评分的总体混合效应，尽管有一些迹象表明，随着NHSII中营养物质的总体混合增加，SRS评分会降低。在这种混合物的背景下，没有观察到叶酸的关联，但保持其他营养固定，n-6 PUFAs与NHSII中较低的SRS评分相关。在这两个队列中，尽管不同队列的蔬菜类型不同，但观察到某些类别的蔬菜摄入量较高，SRS评分较低，并且一些蔬菜组在NHSII中与较高的SRS评分相关。我们的工作扩展了先前的研究，并表明需要从综合影响的角度进一步考虑产前饮食因素。此外，这里的发现指出了基于自闭症家族史的营养关联的潜在差异，这表明需要在未来的工作中考虑基因相互作用。
Prior work has suggested relationships between prenatal intake of certain nutrients and autism. We examined a broad set of prenatal nutrients and foods using a Bayesian modeling approach. Participants were drawn from the Early Autism Risks Longitudinal Investigation (n = 127), a cohort following women with a child with autism through a subsequent pregnancy. Participants were also drawn from the Nurses’ Health Study II (NHSII, n = 713), a cohort of United States female nurses, for comparison analyses. In both studies, information on prospectively reported prenatal diet was drawn from food frequency questionnaires, and child autism-related traits were measured by the Social Responsiveness Scale (SRS). Bayesian kernel machine regression was used to examine the combined effects of several nutrients with neurodevelopmental relevance, including polyunsaturated fatty acids (PUFAs), iron, zinc, vitamin D, folate, and other methyl donors, and separately, key food sources of these, in association with child SRS scores in crude and adjusted models. In adjusted analyses, the overall mixture effects of nutrients in Early Autism Risks Longitudinal Investigation and foods in both cohorts on SRS scores were not observed, though there was some suggestion of decreasing SRS scores with increasing overall nutrient mixture in NHSII. No associations were observed with folate within the context of this mixture, but holding other nutrients fixed, n–6 PUFAs were associated with lower SRS scores in NHSII. In both cohorts, lower SRS scores were observed with higher intake of some groupings of vegetables, though for differing types of vegetables across cohorts, and some vegetable groups were associated with higher SRS scores in NHSII. Our work extends prior research and suggests the need to further consider prenatal dietary factors from a combined effects perspective. In addition, findings here point to potential differences in nutrient associations based on a family history of autism, which suggests the need to consider gene interactions in future work.
影响因子：
4.7
作者：
Joyce, Emily E.;Chavarro, Jorge E.;Rando, Juliette;Song, Ashley Y.;Croen, Lisa A.;Fallin, M. Daniele;Hertz-Picciotto, Irva;Schmidt, Rebecca J.;Volk, Heather;Newschaffer, Craig J.;Lyall, Kristen
通讯作者：
Lyall, Kristen