Prenatal exposure to pesticide residues in the diet in association with child autism-related traits: Results from the EARLI study.
Prenatal exposure to pesticide residues in the diet in association with child autism-related traits: Results from the EARLI study.
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DOI：
10.1002/aur.2698
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发表时间：
2022-05
期刊：
影响因子：
4.7
通讯作者：
Lyall, Kristen
中科院分区：
文献类型：
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作者：
Joyce, Emily E.;Chavarro, Jorge E.;Rando, Juliette;Song, Ashley Y.;Croen, Lisa A.;Fallin, M. Daniele;Hertz-Picciotto, Irva;Schmidt, Rebecca J.;Volk, Heather;Newschaffer, Craig J.;Lyall, Kristen
先前的研究表明，产前暴露于几种杀虫剂与儿童自闭症谱系障碍（ASD）之间存在关联。我们研究了先前开发的农药残留负担评分（PRBS）和高农药残留食物的摄入与ASD相关性状的关系。参与者是从早期自闭症风险纵向调查（EARLI） （n = 256）中抽取的，这是一个队列，跟踪那些之前有过自闭症儿童的母亲，通过随后的怀孕和孩子的发育。根据3岁时社会反应量表（SRS）的总得分（平均原始总SRS得分= 35.8）捕获ASD相关特征。通过在怀孕期间收集的食物频率问卷来评估饮食摄入量。我们还在改良版的PRBS中加入了有机摄入和高脂肪食物。使用多变量线性回归评估高残留水果和蔬菜摄入量、总体PRBS及其修改版本和SRS评分之间的关系。总的来说，我们没有观察到食品中农药残留与ASD相关结果之间的关联，修改后的PRBS也得到了类似的结果。然而，随着水果和蔬菜摄入量的增加，ASD相关性状的减少被观察到（第四季度与第一季度的调整估计：β - 12.76, 95%CI - 27.8, 2.3）。因此，根据PRBS和ASD相关特征，这个高家族概率队列的研究结果并不表明饮食中农药残留之间存在关系。水果和蔬菜摄入的有益影响可能会影响这些关系。未来的工作应该考虑水果和蔬菜摄入量与ASD相关结果的关系。饮食是目前使用的大多数农药的主要接触来源。在这项研究中，我们研究了怀孕期间饮食中农药残留暴露与儿童自闭症相关特征之间的关系。我们发现饮食中的农药残留与儿童三岁时自闭症相关的结果无关。然而，产前较高的水果和蔬菜摄入量与儿童自闭症相关特征的减少有关。
Prior work has suggested associations between prenatal exposure to several classes of pesticides and child autism spectrum disorder (ASD). We examined a previously developed pesticide residue burden score (PRBS) and intake of high pesticide residue foods in association with ASD‐related traits. Participants were drawn from the Early Autism Risk Longitudinal Investigation (EARLI) (n = 256), a cohort following mothers who previously had a child with ASD through a subsequent pregnancy and that child's development. ASD‐related traits were captured according to total Social Responsiveness Scale (SRS) scores at age 3 (mean raw total SRS score = 35.8). Dietary intake was assessed through a food frequency questionnaire collected during pregnancy. We also incorporated organic intake and fatty foods in modified versions of the PRBS. Associations between high‐residue fruit and vegetable intake, the overall PRBS and modified versions of it, and SRS scores were assessed using multivariable linear regression. Overall, we did not observe associations between pesticide residues in foods and ASD‐related outcomes, and modified versions of the PRBS yielded similar findings. However, reductions in ASD‐related traits were observed with higher overall fruit and vegetable intake (adjusted estimates for Q4 vs. Q1: β −12.76, 95%CI −27.8, 2.3). Thus, findings from this high familial probability cohort did not suggest relationships between pesticide residues in the diet according to the PRBS and ASD‐related traits. Beneficial effects of fruit and vegetable intake may influence these relationships. Future work should consider fruit and vegetable intake in association with ASD‐related outcomes. Diet is the main source of exposure to most pesticides in use today. In this study, we examined the relationship between pesticide exposure from residues in the diet during pregnancy and child autism‐related traits. We found that these pesticide residues from the diet were not related to child autism‐related outcomes at age three. However, higher prenatal fruit and vegetable intake was associated with reductions in child autism‐related traits.
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年轻墨西哥裔美国儿童的有机磷酸农药暴露和神经发育。
影响因子：
10.4
作者：
Eskenazi, Brenda;Marks, Amy R.;Bradman, Asa;Harley, Kim;Barr, Dana B.;Johnson, Caroline;Morga, Norma;Jewell, Nicholas A.
通讯作者：
Jewell, Nicholas A.
影响因子：
11.8
作者：
Chiu YH;Williams PL;Gillman MW;Hauser R;Rifas-Shiman SL;Bellavia A;Fleisch AF;Oken E;Chavarro JE
通讯作者：
Chavarro JE
影响因子：
10.4
作者：
Braun JM;Kalkbrenner AE;Just AC;Yolton K;Calafat AM;Sjödin A;Hauser R;Webster GM;Chen A;Lanphear BP
通讯作者：
Lanphear BP
影响因子：
9.3
作者：
De Felice A;Greco A;Calamandrei G;Minghetti L
通讯作者：
Minghetti L
DOI：
10.1176/appi.ajp.2018.17101129
发表时间：
2018-11-01
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Brown AS;Cheslack-Postava K;Rantakokko P;Kiviranta H;Hinkka-Yli-Salomäki S;McKeague IW;Surcel HM;Sourander A
通讯作者：
Sourander A