Schistosoma mansoni excretory-secretory products induce protein kinase signalling, hyperkinesia, and stem cell proliferation in the opposite sex.
Schistosoma mansoni excretory-secretory products induce protein kinase signalling, hyperkinesia, and stem cell proliferation in the opposite sex.
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DOI：
10.1038/s42003-023-05333-9
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发表时间：
2023-09-26
影响因子：
5.9
通讯作者：
Walker, Anthony J.
中科院分区：
文献类型：
--
作者：
Shakir, Eman M. N.;Rinaldi, Gabriel;Kirk, Ruth S.;Walker, Anthony J.
成年雄性和雌性血吸虫寄生在人类血管内并产卵，导致主要的被忽视的热带病人类血吸虫病。人们对男性和女性如何相互交流知之甚少；然而，男女之间的身体互动是很重要的。在这里，我们研究了成熟的曼氏血吸虫释放到外部环境中的排泄产物（ESPs）是否会引起异性的反应。我们证明，ESPs粘附在异性蠕虫的表面，诱导细胞外信号调节激酶（ERK）和p38丝裂原活化蛋白激酶（p38 MAPK）途径的激活，特别是在寄生虫被皮中。此外，我们发现成熟的蠕虫刺激了幼虫的信号传导。引人注目的是，我们证明了来自异性的esp以ERK-和p38 mapk依赖的方式促进雄性被皮和睾丸内以及雌性卵巢和卵黄中的干细胞增殖。在异性ESP暴露后也会出现运动亢进。我们的研究结果支持了一种假设，即雄性和雌性血吸虫可能通过远距离交流来调节蠕虫发育和疾病进展的关键过程，为血吸虫病控制开辟了独特的途径。成熟的曼氏血吸虫通过ERK和p38 MAPK通路释放出调节异性血吸虫关键过程的排泄分泌产物（ESPs），表明雄性和雌性血吸虫可以远距离交流。
Adult male and female schistosomes in copula dwell within human blood vessels and lay eggs that cause the major Neglected Tropical Disease human schistosomiasis. How males and females communicate to each other is poorly understood; however, male-female physical interaction is known to be important. Here, we investigate whether excretory-secretory products (ESPs), released into the external milieu by mature Schistosoma mansoni, might induce responses in the opposite sex. We demonstrate that ESPs adhere to the surface of opposite sex worms inducing the activation of extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (p38 MAPK) pathways, particularly in the parasite tegument. Furthermore, we show that mature worms stimulated signalling in juvenile worms. Strikingly, we demonstrate that ESPs from the opposite sex promote stem cell proliferation, in an ERK- and p38 MAPK-dependent manner, in the tegument and within the testes of males, and the ovaries and vitellaria of females. Hyperkinesia also occurs following opposite sex ESP exposure. Our findings support the hypothesis that male and female schistosomes may communicate over distance to modulate key processes underlying worm development and disease progression, opening unique avenues for schistosomiasis control. Mature Schistosoma mansoni worms release excretory secretory products (ESPs) which modulate key processes in worms of the opposite sex via the ERK and p38 MAPK pathways, indicating that male and female schistosomes can communicate over distances.
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影响因子：
1.5
作者：
Carson JP;Robinson MW;Hsieh MH;Cody J;Le L;You H;McManus DP;Gobert GN
通讯作者：
Gobert GN
影响因子：
2.1
作者：
EVELAND, LK;FRIED, B;COHEN, LM
通讯作者：
COHEN, LM
影响因子：
--
作者：
Crosnier, Cecile;Brandt, Cordelia;Wright, Gavin J
通讯作者：
Wright, Gavin J
影响因子：
4
作者：
Hirst, Natasha L.;Lawton, Scott P.;Walker, Anthony J.
通讯作者：
Walker, Anthony J.
影响因子：
3.8
作者：
Hirst, Natasha L.;Nebel, Jean-Christophe;Walker, Anthony J.
通讯作者：
Walker, Anthony J.