Analysis of Serum Trace Elements ( Copper , Iron and Zinc ) Level in Women with Breast Cancer

DOI: 10.21276/sjams.2017.5.11.22 Abstract: Breast cancer is one of the mainly common cancers in females and highly assorted disease worldwide. ICMR said in 2016 the total number of new cancer cases is likely to be about 14.5 lakh in India. Trace elements are present in small levels, but they act a vital part in plentiful biochemical enzymatic reactions and have been evaluated as a potential key constituent in various human diseases involving cancer. Natural trace elements such as: zinc, copper have some dictatorial functions that may affect immune reactions and free radical generation. The cancerous tissue directly indicates changes of trace elements that are evoked by the disease. Blood or blood constituents such as serum are considered to be the best indicators of the present exposure of an individual to many metals due to its easy sampling. In our study I was include 100 cases and 100 healthy control in which, Serum iron, copper, tumour marker CA15-3 level, Cu/Zn and Cu/Cp ratio were significantly high in breast cancer patient (p<0.001) and. Serum Zinc level is significantly decreased in breast cancer patient (p<0.001).

DOI：10.21276/sjams.2017.5.11.22 摘要：乳腺癌是女性中最常见的癌症之一，在世界范围内是一种高度多样化的疾病。印度医学研究委员会在2016年表示，印度新增癌症病例总数可能约为145万例。微量元素含量较低，但在众多生化酶促反应中起着至关重要的作用，并且已被评估为包括癌症在内的多种人类疾病的潜在关键成分。天然微量元素，如锌、铜，具有一些决定性的功能，可能会影响免疫反应和自由基的产生。癌变组织直接显示出由疾病引起的微量元素的变化。血液或血液成分（如血清）由于其易于采集，被认为是个体当前接触多种金属的最佳指标。在我们的研究中，纳入了100例病例和100例健康对照，其中乳腺癌患者的血清铁、铜、肿瘤标志物CA15 - 3水平、铜/锌和铜/铜蓝蛋白比值显著升高（p<0.001），而乳腺癌患者的血清锌水平显著降低（p<0.001）。