Effect of treatments for depression on quality of life: a meta-analysis.
Effect of treatments for depression on quality of life: a meta-analysis.
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DOI：
10.1080/16506073.2017.1304445
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发表时间：
2017-06
影响因子：
4.7
通讯作者：
Kind S
中科院分区：
文献类型：
--
作者：
Hofmann SG;Curtiss J;Carpenter JK;Kind S
认知行为疗法(CBT)和选择性5-羟色胺再摄取抑制剂(SSRI)是治疗抑郁症的两种一线疗法，但人们对它们对生活质量的影响知之甚少。目的：探讨这两种干预方法对抑郁症患者生活质量的影响。一项荟萃分析被用来检验接受CBT(24项研究，涉及1,969名患者)或SSRI治疗(13项研究，涉及4,286名患者)治疗抑郁症的成年抑郁症患者的生活质量变化。从治疗前到治疗后，CBT(Hedge‘s g=0.63)和SSRI(Hedge’s g=0.79)治疗均有适度的生活质量改善。在CBT的随访期内，效应大小保持稳定。没有数据可以用来检查SSRI组的随访情况。生活质量效应大小随着发表年限呈线性下降，抑郁症的更大改善与CBT的生活质量更大的改善显著相关，但与SSRI无关。CBT和SSRIs治疗抑郁症都与生活质量的适度改善有关，但可能是由不同的机制引起的。
Cognitive-behavioral therapy (CBT) and selective serotonin reuptake inhibitors (SSRIs) are the two first-line treatments for depression, but little is known about their effects on quality of life. To investigate the efficacy of these two interventions for depression on quality of life (QOL). A meta-analysis was conducted to examine changes in QOL in adults with major depressive disorder who received CBT (24 studies examining 1,969 patients) or SSRI treatment (13 studies examining 4,286 patients) for their depression. Moderate improvements in QOL from pre to post-treatment were observed in both CBT (Hedges’ g = 0.63) and SSRI (Hedges’ g = 0.79) treatments. The effect size remained stable over the course of the follow-up period for CBT. No data were available to examine follow-ups in the SSRI group. QOL effect sizes decreased linearly with publication year, and greater improvements in depression were significantly associated with greater improvement in QOL for CBT, but not for SSRIs. CBT and SSRIs for depression were both associated with moderate improvements in QOL, but are possibly caused by different mechanisms.
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