Prostaglandins of J Series Control Heme Oxygenase Expression
Prostaglandins of J Series Control Heme Oxygenase Expression
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J 系列前列腺素控制血红素加氧酶表达
DOI：
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发表时间：
2003
影响因子：
5.2
通讯作者：
S. Doré
中科院分区：
文献类型：
--
作者：
H. Zhuang;Y. Kim;K. Namiranian;S. Doré
Abstract: Cyclopentenone prostaglandins (cyPGs) are a subfamily of prostaglandins that are characterized by the cyclopentenone ring in their structure. They exert their effect after active transportation into the cell, probably by interacting with cellular target proteins or DNA sequences. The cyPGs have anti‐inflammatory activities, especially important during the resolution of inflammation, anticancer, and cytoprotective properties. Here, we show that the cyPGs, especially the 15‐deoxy‐Δ12,14 PGJ2, can specifically induce heme oxygenase 1 in mouse primary neuronal cells. Heme oxygenase is the enzyme responsible for the degradation of heme into biliverdin, ferrous iron, and carbon monoxide. This enzyme conveys protection to oxidative cellular injury by degrading the pro‐inflammatory heme; producing biliverdin and bilirubin, potent antioxidants; producing carbon monoxide, a neurotransmitter that also has anti‐inflammatory and vasodilatory properties; and assisting in keeping iron cellular homeostasis. CyPGs appear to possess a promising future in designing therapeutics for many neurologic diseases, such as Alzheimer's disease, vascular‐related dementia, multiple sclerosis, ischemic conditions, and many others in which inflammation is a part of the pathophysiology.
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DOI：
10.1073/pnas.96.8.4668
发表时间：
1999-04-13
影响因子：
11.1
作者：
Petrova, TV;Akama, KT;Van Eldik, LJ
通讯作者：
Van Eldik, LJ
影响因子：
56.9
作者：
VERMA, A;HIRSCH, DJ;SNYDER, SH
通讯作者：
SNYDER, SH
前列腺素 A2 特异性抑制 C6 大鼠神经胶质瘤细胞中胰岛素样生长因子-I 基因的表达。
影响因子：
4.8
作者：
Bui,T;Kuo,C;Rotwein,P;Straus,DS
通讯作者：
Straus,DS
DOI：
--
发表时间：
2002-09
期刊：
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research
影响因子：
--
作者：
P. A. Campo;Sonali Das;C. Hsiang;T. Bui;C. E. Samuel;D. Straus
通讯作者：
P. A. Campo;Sonali Das;C. Hsiang;T. Bui;C. E. Samuel;D. Straus
影响因子：
19.6
作者：
Nath, KA;Croatt, AJ;Grande, JP
通讯作者：
Grande, JP