Choriocapillaris changes in dry age-related macular degeneration and geographic atrophy: a review.
Choriocapillaris changes in dry age-related macular degeneration and geographic atrophy: a review.
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DOI：
10.1186/s40662-018-0118-x
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Waheed NK
中科院分区：
文献类型：
--
作者：
Arya M;Sabrosa AS;Duker JS;Waheed NK
年龄相关性黄斑变性（AMD）是世界范围内中枢性视力丧失的主要原因。干性黄斑变性从早期到中期的进展主要表现为增加黄斑形成和对视网膜外细胞的不利影响。晚期AMD包括地理萎缩（GA），非渗出性（干性）AMD亚型，或脉络膜新生血管形成，渗出性（湿性）AMD亚型。GA的特征是视网膜外和脉络膜萎缩，特别是光感受器层、RPE和脉络膜毛细血管。关于AMD进展的发病机制和GA的后续发展仍有待发现。由于所有三层的功能密切相关，因此最终导致萎缩的事件的时间顺序对于理解该疾病的致病途径非常重要。OCTA的出现，特别是扫描源技术的出现，使得视网膜血管和绒毛膜毛细血管的深度分辨率成像成为可能。随着OCTA的使用，最近的研究表明，绒毛膜毛细血管血流改变与AMD的发生和进展密切相关。这些变化甚至可能对确定GA的进展提供预测价值。本文综述了干性AMD中绒毛膜毛细血管变化的研究，并总结了绒毛膜毛细血管作为AMD发病关键因素的潜在作用。
Age-related macular degeneration (AMD) is a leading cause of central vision loss worldwide. The progression of dry AMD from early to intermediate stages is primarily characterized by increasing drusen formation and adverse impact on outer retinal cells. Late stage AMD consists of either geographic atrophy (GA), the non-exudative (dry) AMD subtype, or choroidal neovascularization, the exudative (wet) AMD subtype. GA is characterized by outer retinal and choroidal atrophy, specifically the photoreceptor layer, RPE, and choriocapillaris. Much remains to be discovered regarding the pathogenesis of AMD progression and subsequent development of GA. As the functionality of all three layers is closely linked, the temporal sequence of events that end up in atrophy is important in the understanding of the pathogenic pathway of the disease. The advent of OCTA, and particularly of swept-source technology, has allowed for depth-resolved imaging of retinal vasculature and the choriocapillaris. With the use of OCTA, recent studies demonstrate that choriocapillaris flow alterations are closely associated with the development and progression of AMD. Such changes may even possibly offer predictive value in determining progression of GA. This article reviews studies demonstrating choriocapillaris changes in dry AMD and summarizes the existing literature on the potential role of the choriocapillaris as a key factor in the pathogenesis of AMD.
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影响因子：
17.8
作者：
Ferrara, Daniela;Waheed, Nadia K.;Duker, Jay S.
通讯作者：
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影响因子：
13.7
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4.4
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56.9
作者：
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通讯作者：
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4.2
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通讯作者：
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