Measuring and evaluating the role of ATP-sensitive K+ channels in cardiac muscle.
Measuring and evaluating the role of ATP-sensitive K+ channels in cardiac muscle.
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测量和评估 ATP 敏感 K 通道在心肌中的作用。
DOI：
10.1016/j.yjmcc.2011.12.012
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发表时间：
2012
影响因子：
5
通讯作者：
Coetzee,WilliamA
中科院分区：
文献类型：
--
作者：
Kefaloyianni,Eirini;Bao,Li;Rindler,MichaelJ;Hong,Miyoun;Patel,Tejaskumar;Taskin,Eylem;Coetzee,WilliamA
Since ion channels move electrical charge during their activity, they have traditionally been studied using electrophysiological approaches. This was sometimes combined with mathematical models, for example with the description of the ionic mechanisms underlying the initiation and propagation of action potentials in the squid giant axon by Hodgkin and Huxley. The methods for studying ion channels also have strong roots in protein chemistry (limited proteolysis, the use of antibodies, etc.). The advent of the molecular cloning and the identification of genes coding for specific ion channel subunits in the late 1980s introduced a multitude of new techniques with which to study ion channels and the field has been rapidly expanding ever since (e.g. antibody development against specific peptide sequences, mutagenesis, the use of gene targeting in animal models, determination of their protein structures) and new methods are still in development. This review focuses on techniques commonly employed to examine ion channel function in an electrophysiological laboratory. The focus is on the KATPchannel, but many of the techniques described are also used to study other ion channels.
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影响因子：
11.2
作者：
B. Katzenellenbogen;Kari L. Kendra;M. Norman;Y. Berthois
通讯作者：
B. Katzenellenbogen;Kari L. Kendra;M. Norman;Y. Berthois
雌激素依赖性 MCF-7 细胞对低雌激素（无酚红）培养的适应。
DOI：
10.1016/0277-5379(87)90062-9
发表时间：
1987
期刊：
European journal of cancer & clinical oncology
影响因子：
--
作者：
Welshons,WV;Jordan,VC
通讯作者：
Jordan,VC
他莫昔芬预防：预防胜于治疗——预防就是治疗？
影响因子：
3.6
作者：
V. Jordan
通讯作者：
V. Jordan
致癌基因与类固醇受体同源？
影响因子：
64.8
作者：
M. Sluyser;J. Mester
通讯作者：
J. Mester
酮昔芬和他莫昔芬在 N-亚硝基甲基脲诱导的大鼠乳腺癌模型中的抗肿瘤作用。
影响因子：
11.2
作者：
Gottardis,MM;Jordan,VC
通讯作者：
Jordan,VC