Localized reductions in resting-state functional connectivity in children with prenatal alcohol exposure.
Localized reductions in resting-state functional connectivity in children with prenatal alcohol exposure.
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DOI：
10.1002/hbm.23726
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发表时间：
2017-10
影响因子：
4.8
通讯作者：
Meintjes EM
中科院分区：
文献类型：
--
作者：
Fan J;Taylor PA;Jacobson SW;Molteno CD;Gohel S;Biswal BB;Jacobson JL;Meintjes EM
胎儿酒精谱系障碍（FASD）以认知功能障碍为特征，可能或可能不伴有颅面异常、小头畸形和/或生长迟缓。静息状态功能MRI （rs-fMRI）在没有明确任务的情况下检测血氧水平依赖（BOLD）信号的低频成分，为研究低功能和年轻受试者的功能性脑网络提供了一种有效而强大的机制。使用独立成分分析（ICA）的研究已经确定了一组与认知和感知功能的不同领域相关的静息状态网络（rsn），这些网络被认为反映了大脑的内在功能结构。这项研究首次检测了FASD中这些rsn的静息状态功能连接。对来自开普敦纵向队列的38名FASD儿童（19名为完全胎儿酒精综合征（FAS）或部分胎儿酒精综合征（PFAS）， 19名非综合征性重度暴露（HE））和19名对照组进行Rs-fMRI扫描，平均年龄11.3±0.9岁。通过ICA生成了9个静息状态网络。在联合FAS/PFAS组和对照组之间的体素组比较显示，在单独的网络中，前部默认模式、显著性、腹侧和背侧注意以及R执行控制五个区域的局部剂量依赖性功能连接减少。前三组在高智商组中也表现出较低的连通性。这5个网络中有4个的灰质连通性缺陷似乎与提供rsn内部连接的白质束缺陷有关。中国生物医学工程学报（英文版），2017。
Fetal alcohol spectrum disorders (FASD) are characterized by impairment in cognitive function that may or may not be accompanied by craniofacial anomalies, microcephaly, and/or growth retardation. Resting-state functional MRI (rs-fMRI), which examines the low-frequency component of the blood oxygen level dependent (BOLD) signal in the absence of an explicit task, provides an efficient and powerful mechanism for studying functional brain networks even in low-functioning and young subjects. Studies using independent component analysis (ICA) have identified a set of resting-state networks (RSNs) that have been linked to distinct domains of cognitive and perceptual function, which are believed to reflect the intrinsic functional architecture of the brain. This study is the first to examine resting-state functional connectivity within these RSNs in FASD. Rs-fMRI scans were performed on 38 children with FASD (19 with either full fetal alcohol syndrome (FAS) or partial FAS (PFAS), 19 nonsyndromal heavily exposed (HE)), and 19 controls, mean age 11.3±0.9 years, from the Cape Town Longitudinal Cohort. Nine resting-state networks were generated by ICA. Voxelwise group comparison between a combined FAS/PFAS group and controls revealed localized dose-dependent functional connectivity reductions in five regions in separate networks: anterior default mode, salience, ventral and dorsal attention, and R executive control. The former three also showed lower connectivity in the HE group. Gray matter connectivity deficits in four of the five networks appear to be related to deficits in white matter tracts that provide intra-RSN connections. Hum Brain Mapp 38:5217–5233, 2017.
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影响因子：
4.8
作者：
Fan, Jia;Jacobson, Sandra W.;Taylor, Paul A.;Molteno, Christopher D.;Dodge, Neil C.;Stanton, Mark E.;Jacobson, Joseph L.;Meintjes, Ernesta M.
通讯作者：
Meintjes, Ernesta M.
影响因子：
5.3
作者：
Bonnelle, Valerie;Leech, Robert;Sharp, David J.
通讯作者：
Sharp, David J.
DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
Beckmann, CF;DeLuca, M;Smith, SM
通讯作者：
Smith, SM
影响因子：
2.9
作者：
Dodge, Neil C.;Jacobson, Joseph L.;Jacobson, Sandra W.
通讯作者：
Jacobson, Sandra W.
DOI：
10.1073/pnas.0601417103
发表时间：
2006-09-12
影响因子：
11.1
作者：
Damoiseaux, J. S.;Rombouts, S. A. R. B.;Beckmann, C. F.
通讯作者：
Beckmann, C. F.