White matter deficits mediate effects of prenatal alcohol exposure on cognitive development in childhood.
White matter deficits mediate effects of prenatal alcohol exposure on cognitive development in childhood.
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DOI：
10.1002/hbm.23218
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发表时间：
2016-08
影响因子：
4.8
通讯作者：
Meintjes, Ernesta M.
中科院分区：
文献类型：
--
作者：
Fan, Jia;Jacobson, Sandra W.;Taylor, Paul A.;Molteno, Christopher D.;Dodge, Neil C.;Stanton, Mark E.;Jacobson, Joseph L.;Meintjes, Ernesta M.
关键词：
胎儿酒精谱系障碍包括由产前酒精暴露（PAE）引起的认知、行为和神经损伤。对来自开普敦纵向队列的54名儿童（年龄10.1 ±1.0岁）进行了弥散张量成像（DTI），这些儿童在怀孕期间获得了详细的饮酒史：26名患有完全胎儿酒精综合征（FAS）或部分FAS（PFAS），15名非综合征重度暴露（HE），13名对照。使用voxelwise分析，FAS/PFAS的儿童表现出显着较低的分数各向异性（FA）在四个白色物质（WM）区域和较高的平均扩散率（MD）在七个; FA和MD差异（左下纵束（ILF），压部，峡部）的三个区域重叠，第四FA集群位于同一WM束（右ILF）作为MD集群。HE儿童在这些区域的一个子集中表现出较低的FA和较高的MD。三个连续的酒精测量和DTI值之间的显着相关性，观察到在集群峰值，表明WM在几个地区的损害是剂量依赖性的。感兴趣区域的FA较低主要归因于径向扩散率增加，而不是轴突扩散率降低，这表明轴突堆积密度和/或髓鞘形成较差。多元回归模型表明，这种皮层WM损害部分介导的不良影响PAE的信息处理速度和眨眼条件。
Fetal alcohol spectrum disorders comprise the spectrum of cognitive, behavioral, and neurological impairments caused by prenatal alcohol exposure (PAE). Diffusion tensor imaging (DTI) was performed on 54 children (age 10.1 ±1.0 years) from the Cape Town Longitudinal Cohort, for whom detailed drinking histories obtained during pregnancy are available: 26 with full fetal alcohol syndrome (FAS) or partial FAS (PFAS), 15 nonsyndromal heavily exposed (HE), and 13 controls. Using voxelwise analyses, children with FAS/PFAS showed significantly lower fractional anisotropy (FA) in four white matter (WM) regions and higher mean diffusivity (MD) in seven; three regions of FA and MD differences (left inferior longitudinal fasciculus (ILF), splenium, and isthmus) overlapped, and the fourth FA cluster was located in the same WM bundle (right ILF) as an MD cluster. HE children showed lower FA and higher MD in a subset of these regions. Significant correlations were observed between three continuous alcohol measures and DTI values at cluster peaks, indicating that WM damage in several regions is dose dependent. Lower FA in the regions of interest was attributable primarily to increased radial diffusivity rather than decreased axonal diffusivity, suggesting poorer axon packing density and/or myelination. Multiple regression models indicated that this cortical WM impairment partially mediated adverse effects of PAE on information processing speed and eyeblink conditioning.
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影响因子：
7.6
作者：
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通讯作者：
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通讯作者：
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作者：
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通讯作者：
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