Modeling and Estimating Recall Processing Capacity: Sensitivity and Diagnostic Utility in Application to Mild Cognitive Impairment.
Modeling and Estimating Recall Processing Capacity: Sensitivity and Diagnostic Utility in Application to Mild Cognitive Impairment.
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DOI：
10.1016/j.jmp.2009.04.012
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发表时间：
2010-02-01
影响因子：
1.8
通讯作者：
Petersen L
中科院分区：
文献类型：
--
作者：
Wenger MK;Negash S;Petersen RC;Petersen L
我们研究了使用基于潜伏期的检索处理能力测量来评估患有轻度认知障碍（MCI）的个体的表现变化的可能性，轻度认知障碍是阿尔茨海默病的可靠前兆。使用这些容量测量的部分动机是探索萎缩对基本海马回路计算模型的影响。我们使用这个模型来表明，容量可能是比处理速度更敏感的潜在萎缩指标，并通过采用标准的记忆行为测量（自由和线索选择性提醒测试，FCSRT）来测试这一假设，以允许收集线索回忆潜伏期。参与者来自五组：大学生、中年人、健康老年人、被诊断为轻度认知障碍的人，以及轻度认知障碍对照组的样本。与标准行为测量相比，能力测量显示出更高的分类敏感性，而且也显示出与海马体积相关性最强的行为测量。
We investigate the potential for using latency-based measures of retrieval processing capacity to assess changes in perfomance specific to individuals with mild cognitive impairment (MCI), a reliable precursor state to Alzheimer's Disease. Use of these capacity measures is motivated in part by exploration of the effects of atrophy on a computational model of a basic hippocampal circuit. We use this model to suggest that capacity may be a more sensitive indicator of undelying atrophy than speed of processing, and test this hypothesis by adapting a standard behavioral measure of memory (the free and cued selective reminding test, FCSRT) to allow for the collection of cued recall latencies. Participants were drawn from five groups: college-aged, middle-aged, healthy elderly, those with a diagnosis of MCI, and a sample of MCI control participants. The measure of capacity is shown to offer increased classificatory sensitivity relative to the standard behavioral measures, and is also shown to be the behavioral measure that correlated most strongly with hippocampal volume.
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影响因子：
3.5
作者：
Fisher, DL;Glaser, RA
通讯作者：
Glaser, RA
影响因子：
--
作者：
Dickerson, Bradford C.;Sperling, Reisa A.;Blacker, Deborah
通讯作者：
Blacker, Deborah
DOI：
10.1016/s0022-5371(73)80034-9
发表时间：
1973-01-01
期刊：
JOURNAL OF VERBAL LEARNING AND VERBAL BEHAVIOR
影响因子：
--
作者：
BUSCHKE, H
通讯作者：
BUSCHKE, H
影响因子：
2.5
作者：
Davachi, L;Wagner, AD
通讯作者：
Wagner, AD
影响因子：
2.6
作者：
FISHER, DL
通讯作者：
FISHER, DL