Aging, Health, and Quality of Life for Older People Living With HIV in Sub-Saharan Africa: A Review and Proposed Conceptual Framework.

Aging, Health, and Quality of Life for Older People Living With HIV in Sub-Saharan Africa: A Review and Proposed Conceptual Framework.
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DOI:
10.1177/0898264317724549
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发表时间:
2019-01
影响因子:
2.8
通讯作者:
Siedner MJ
Siedner MJ
中科院分区:
医学3区
文献类型:
--
作者:
Siedner MJ

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在撒哈拉以南非洲,50岁以上的艾滋病毒感染者人数预计在未来几十年内将增加两倍,达到600万至1000万。然而,关于该区域老年艾滋病毒/艾滋病感染者健康和生活质量的决定因素的数据很少。进行了一项审查,以描述艾滋病毒感染对撒哈拉以南非洲艾滋病毒携带者老龄化的影响。我们(a)总结了艾滋病毒在资源丰富的环境中老化的病理生理学和流行病学,(B)描述了这些关系在撒哈拉以南非洲可能会有所不同,(c)提出了一个概念框架,以描述老年人生活质量的决定因素,(d)建议优先研究领域,以确保该地区的生活质量的长期收益。传统、生活方式和环境风险因素的差异,以及艾滋病毒流行病学和护理提供的独特特征,似乎大大改变了艾滋病毒对撒哈拉以南非洲老龄化的影响。与此同时,生活质量的独特偏好和概念化将需要新颖的测量和干预工具。需要扩大研究和公共卫生基础设施,以确保在艾滋病毒预防和治疗方面取得的成果转化为该区域的长期利益。
The number of people living with HIV (PLWH) over 50 years old in sub-Saharan Africa is predicted to triple in the coming decades, to 6-10 million. Yet, there is a paucity of data on the determinants of health and quality of life for older PLWH in the region. A review was undertaken to describe the impact of HIV infection on aging for PLWH in sub-Saharan Africa. We (a) summarize the pathophysiology and epidemiology of aging with HIV in resource-rich settings, and (b) describe how these relationships might differ in sub-Saharan Africa, (c) propose a conceptual framework to describe determinants of quality of life for older PLWH, and (d) suggest priority research areas needed to ensure long-term gains in quality of life for PLWH in the region. Differences in traditional, lifestyle, and envirnomental risk factors, as well as unique features of HIV epidemiology and care delivery appear to substantially alter the contribution of HIV to aging in sub-Saharan Africa. Meanwhile, unique preferences and conceptualizations of quality of life will require novel measurement and intervention tools. An expanded research and public health infrastructure is needed to ensure that gains made in HIV prevention and treamtent are translated into long-term benefits in this region.
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