Direct Catalytic Asymmetric Aldol Reaction of Thioamide with an α-Vinyl Appendage.
Direct Catalytic Asymmetric Aldol Reaction of Thioamide with an α-Vinyl Appendage.
复制标题
硫代酰胺与 α-乙烯基附属物的直接催化不对称羟醛反应。
作者：
Jin Cui;Akimichi Ohtsuki;Takumi Watanabe;N. Kumagai;M. Shibasaki
直接催化不对称羟醛缩合反应是一种新兴的催化方法，它提供了原子经济的功能化手性构件。硫代酰胺是有用的羟醛供体，由于其高保真的化学选择性烯醇化和不同的后羟醛转化。本文中，我们描述了在硫代酰胺上引入α-乙烯基附件，这扩展了羟醛加合物在天然产物合成中的用途。这种乙烯基化硫代酰胺在先前确定的催化剂设置下不被容纳，但是新开发的催化条件提供了含有侧链乙烯基的羟醛产物。
The direct catalytic asymmetric aldol reaction is an emerging catalytic methodology that provides atom-economical access to functionalized chiral building blocks. Thioamides are useful aldol donors due to their high-fidelity chemoselective enolization and divergent post-aldol transformations. Herein we describe the incorporation of an α-vinyl appendage on a thioamide, which expands the utility of aldol adducts for natural product synthesis. This vinylated thioamide was not accommodated under the previously identified catalyst settings, but the newly developed catalytic conditions furnished aldol products containing the pendant vinyl group.
DOI：
10.1002/anie.201302084
发表时间：
2013-08-26
期刊：
Angewandte Chemie (International ed. in English)
影响因子：
--
作者：
Beutner GL;Denmark SE
通讯作者：
Denmark SE
影响因子：
46.2
作者：
Trost BM;Brindle CS
通讯作者：
Brindle CS
利莫西丁内酯甲酯（( )-利莫西丁的苷元）的合成。
DOI：
10.1002/anie.200453697
发表时间：
2004
期刊：
Angewandte Chemie (International ed. in English)
影响因子：
--
作者：
Packard,GarrickK;Hu,Yueqing;Vescovi,Andrea;Rychnovsky,ScottD
通讯作者：
Rychnovsky,ScottD