Polymorphisms in the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with peak bone mass in non-sedentary men: results from the Odense androgen study.
Polymorphisms in the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with peak bone mass in non-sedentary men: results from the Odense androgen study.
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DOI：
10.1007/s00223-007-9088-z
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发表时间：
2007-12
影响因子：
4.2
通讯作者：
Abrahamsen, B.
中科院分区：
文献类型：
--
作者：
Brixen, K.;Beckers, S.;Peeters, A.;Piters, E.;Balemans, W.;Nielsen, T. L.;Wraae, K.;Bathum, L.;Brasen, C.;Hagen, C.;Andersen, M.;Van Hul, W.;Abrahamsen, B.
关键词：
探讨低密度脂蛋白受体相关蛋白5 （LRP5）基因Ala1330Val （rs3736228，外显子18）和Val667Met （rs4988321，外显子9）多态性对青年男性峰值骨量的影响。欧登塞雄激素研究（OAS）是一项基于人群的研究，包括783名20-30岁的高加索男性。采用实时聚合酶链反应（PCR）或荧光偏振法进行基因分型。骨密度（BMD）测量采用双能x线吸收仪。Ala1330Val的CC、CT和TT基因型分别在75.6%、21.8%和2.6%的参与者中发现。Val667Met的GG、GA和AA基因型分别占89.7%、9.8%和0.5%。对于Ala1330Val多态性，在整个研究人群中，没有发现基因型之间在骨密度方面的显著差异。然而，当分析仅限于不久坐的男性（n = 589）时，发现t等位基因数量与脊柱和全身骨密度之间存在显著关联。每个t等位基因拷贝改变脊柱的z -评分（中位数和95%置信区间）为- 0.21 [95% CI: - 0.40；−0.03]（p < 0.02）。分析表明，Val667Met多态性中的AA基因型与身高升高和股骨颈骨密度降低有关；然而，a等位基因在整个人群中没有明显的基因剂量效应。然而，当分析仅限于不久坐的受试者时，每个a等位基因的数量与z评分的变化相关，为- 0.26 [95% CI: - 0.51；−0.01]（p = 0.04）。单倍型分析没有进一步的显著结果。LRP5基因的Ala1330Val和Val667Met多态性与体力活动男性的峰值骨量显著相关。
To investigate the impact of the Ala1330Val (rs3736228, exon 18) and Val667Met (rs4988321, exon 9) polymorphisms of the low-density lipoprotein receptor-related protein 5 (LRP5) gene on peak bone mass in young men. The Odense Androgen Study (OAS) is a population-based study comprising 783 Caucasian men aged 20-30 years. Genotyping was performed using real-time polymerase chain reaction (PCR) or fluorescence polarization. Bone mineral density (BMD) measurements were performed using dual-energy X-ray absorptiometry. The CC, CT, and TT genotypes in Ala1330Val were found in 75.6%, 21.8%, and 2.6% of the participants, respectively. Similarly, the GG, GA, and AA genotypes of Val667Met were found in 89.7%, 9.8%, and 0.5%, respectively. For the Ala1330Val polymorphism, no significant differences between the genotypes were found regarding BMD in the overall study population. However, when analysis was restricted to non-sedentary men (n = 589), a significant association between the number of T-alleles and BMD in the spine and whole body were found. Each copy of the T-allele changed the Z-score of the spine by (median and 95% confidence interval) −0.21 [95% CI: −0.40; −0.03] (p < 0.02). Analysis suggested an association between the AA genotype in the Val667Met polymorphism and increased body height and decreased BMD of the femoral neck; however, no significant gene-dose effect of the A-allele could be demonstrated in the whole population. When the analysis was restricted to non-sedentary subjects, however, each number of A-alleles was associated with a change in Z-score of −0.26 [95% CI: −0.51; −0.01] (p = 0.04). No further significant results emerged with haplotype analysis. The Ala1330Val and Val667Met polymorphisms in the LRP5 gene are significantly associated with peak bone mass in physically active men.
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