Utilizing poxviral vectored vaccines for antibody induction-progress and prospects.
Utilizing poxviral vectored vaccines for antibody induction-progress and prospects.
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DOI：
10.1016/j.vaccine.2013.05.091
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发表时间：
2013-09-06
期刊：
影响因子：
5.5
通讯作者：
Gilbert SC
中科院分区：
文献类型：
--
作者：
Draper SJ;Cottingham MG;Gilbert SC
痘病毒载体现在被认为是 B 细胞和抗体诱导的强大工具。可以针对载体以及转基因诱导抗体反应。异源初免-加强免疫方案的应用不断增加。有效的兽用痘病毒疫苗产品现已获得许可。人体临床试验中报告了抗体诱导的有希望的结果。在过去的十年中，痘病毒载体成为通过疫苗接种诱导 T 细胞介导的免疫的主要方法，其对人类的适用性导致针对传染性细胞内病原体和癌症的候选载体进行了广泛的临床测试。相比之下，痘病毒在疫苗领域被广泛认为是诱导体液免疫的载体的不良选择。然而，来自动物模型和最近临床试验的越来越多的数据现在表明，这些载体可以成功地用于启动和增强 B 细胞以及有效的抗体反应。在异源初免-加强免疫方案方面已经取得了重大进展，痘病毒能够加强由其他载体引发的反应，从而诱导高滴度抗原特异性抗体反应。在其他情况下，痘病毒载体已被证明可以刺激针对自身和编码转基因的体液免疫，特别是病毒表面蛋白，例如流感血凝素。在兽医领域，重组痘病毒载体产生了重大影响，许多载体被许可用于对抗多种动物病毒。正在进行的研究继续探索痘病毒载体调节体液反应的定性方面的潜力，以及它们对寻求提高定量抗体免疫原性的佐剂的适应性。然而，重组痘病毒诱导 B 细胞的基本机制仍不清楚，需要进一步的工作来帮助指导未来旨在诱导抗体的候选痘病毒疫苗的合理优化。
Poxviral vectors are now regarded as robust tools for B cell and antibody induction. Antibody responses can be induced against the vector as well as a transgene. Increasing application is seen in heterologous prime–boost immunization regimes. Effective veterinary poxviral vaccine products are now licensed. Promising results of antibody induction are being reported in human clinical trials. Over the last decade, poxviral vectors emerged as a mainstay approach for the induction of T cell-mediated immunity by vaccination, and their suitability for human use has led to widespread clinical testing of candidate vectors against infectious intracellular pathogens and cancer. In contrast, poxviruses have been widely perceived in the vaccine field as a poor choice of vector for the induction of humoral immunity. However, a growing body of data, from both animal models and recent clinical trials, now suggests that these vectors can be successfully utilized to prime and boost B cells and effective antibody responses. Significant progress has been made in the context of heterologous prime–boost immunization regimes, whereby poxviruses are able to boost responses primed by other vectors, leading to the induction of high-titre antigen-specific antibody responses. In other cases, poxviral vectors have been shown to stimulate humoral immunity against both themselves and encoded transgenes, in particular viral surface proteins such as influenza haemagglutinin. In the veterinary field, recombinant poxviral vectors have made a significant impact with numerous vectors licensed for use against a variety of animal viruses. On-going studies continue to explore the potential of poxviral vectors to modulate qualitative aspects of the humoral response, as well as their amenability to adjuvantation seeking to improve quantitative antibody immunogenicity. Nevertheless, the underlying mechanisms of B cell induction by recombinant poxviruses remain poorly defined, and further work is necessary to help guide the rational optimization of future poxviral vaccine candidates aiming to induce antibodies.
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影响因子：
168.9
作者：
CADOZ, M;STRADY, A;PLOTKIN, S
通讯作者：
PLOTKIN, S
影响因子：
4
作者：
Baum, Jake;Chen, Lin;Cowman, Alan F.
通讯作者：
Cowman, Alan F.
影响因子：
4.4
作者：
Crotty, S;Felgner, P;Ahmed, R
通讯作者：
Ahmed, R
DOI：
10.1073/pnas.191380898
发表时间：
2001-09-25
影响因子：
11.1
作者：
Bruña-Romera, O;González-Aseguinolaza, G;Nussenzweig, RS
通讯作者：
Nussenzweig, RS
DOI：
10.1073/pnas.0408782102
发表时间：
2005-01-18
影响因子：
11.1
作者：
Davies, DH;Liang, XW;Felgner, PL
通讯作者：
Felgner, PL