Fetal radiofrequency radiation exposure from 800-1900 mhz-rated cellular telephones affects neurodevelopment and behavior in mice.
Fetal radiofrequency radiation exposure from 800-1900 mhz-rated cellular telephones affects neurodevelopment and behavior in mice.
复制标题
DOI：
10.1038/srep00312
复制
发表时间：
2012
影响因子：
4.6
通讯作者：
Taylor, Hugh S.
中科院分区：
文献类型：
--
作者：
Aldad, Tamir S.;Gan, Geliang;Gao, Xiao-Bing;Taylor, Hugh S.
神经行为障碍在儿童中越来越普遍，但其病因尚不清楚。出生前使用手机与儿童多动症之间的联系已被推测，然而射频辐射暴露对神经发育的直接影响仍不清楚。在这里，我们使用了一个小鼠模型来证明，宫内手机射频暴露确实会影响成年人的行为。通过物体识别、明暗盒和跳台试验确定，宫内暴露的小鼠活动过度，记忆力受损。微兴奋性突触后电流(MEPSCs)的全细胞膜片钳记录显示，这些行为改变是由于神经元发育程序的改变。暴露小鼠的前额叶皮质V层锥体神经元的谷氨酸能突触传递受到剂量反应的损害。我们提出了由于宫内蜂窝电话辐射引起的神经病理学的第一个实验证据。还需要在人类或非人类灵长类动物身上进行进一步的实验，以确定怀孕期间接触病毒的风险。
Neurobehavioral disorders are increasingly prevalent in children, however their etiology is not well understood. An association between prenatal cellular telephone use and hyperactivity in children has been postulated, yet the direct effects of radiofrequency radiation exposure on neurodevelopment remain unknown. Here we used a mouse model to demonstrate that in-utero radiofrequency exposure from cellular telephones does affect adult behavior. Mice exposed in-utero were hyperactive and had impaired memory as determined using the object recognition, light/dark box and step-down assays. Whole cell patch clamp recordings of miniature excitatory postsynaptic currents (mEPSCs) revealed that these behavioral changes were due to altered neuronal developmental programming. Exposed mice had dose-responsive impaired glutamatergic synaptic transmission onto layer V pyramidal neurons of the prefrontal cortex. We present the first experimental evidence of neuropathology due to in-utero cellular telephone radiation. Further experiments are needed in humans or non-human primates to determine the risk of exposure during pregnancy.
登录
查看更多内容
影响因子：
34.7
作者：
Arnsten, Amy F. T.
通讯作者：
Arnsten, Amy F. T.
DOI：
10.1038/npp.2009.90
发表时间：
2009-11
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1080/15287390902841466
发表时间：
2009-01-01
影响因子：
2.6
作者：
Cao, Yi;Zhang, Wei;Tong, Jian
通讯作者：
Tong, Jian
影响因子：
3.7
作者：
Rubino, T.;Realini, N.;Parolaro, D.
通讯作者：
Parolaro, D.
影响因子：
64.8
作者：
Ungless, MA;Whistler, JL;Bonci, A
通讯作者：
Bonci, A