Genomic Landscapes of EBV-Associated Nasopharyngeal Carcinoma vs. HPV-Associated Head and Neck Cancer.
Genomic Landscapes of EBV-Associated Nasopharyngeal Carcinoma vs. HPV-Associated Head and Neck Cancer.
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DOI：
10.3390/cancers10070210
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发表时间：
2018-06-21
期刊：
影响因子：
5.2
通讯作者：
Lui VWY
中科院分区：
文献类型：
--
作者：
Ngan HL;Wang L;Lo KW;Lui VWY
EB病毒阳性的鼻咽癌(EBV(+)NPC)和人乳头状瘤病毒阳性的头颈部鳞状细胞癌(HPV(+)HNSCC)是两种不同类型的侵袭性头颈部癌，发病年龄较早。最近通过全外显子组测序(WES)确定的基因组图谱清楚地揭示了这些癌症的关键作用：(1)通过核因子-kB激活的炎症，(2)通过PI3K异常的生存，以及(3)通过MHC丢失在这些癌症中的免疫逃避。这些WES研究的直接结果包括确定潜在的预后生物标记物，以及这些癌症的可用药事件。这些基因组学发现对精确医学和免疫疗法的发展的影响将被讨论。对于这两种癌症，主要的致命性来自转移和疾病复发，这可能代表着治疗抵抗。因此，这些癌症的潜在治愈仍然依赖于未来对这些内在侵袭性头颈部癌症复发和转移形式的关键基因组驱动因素和可能的可用药事件的识别。
Epstein-Barr virus-positive nasopharyngeal carcinoma (EBV(+) NPC), and human papillomavirus-positive head and neck squamous cell carcinoma (HPV(+) HNSCC) are two distinct types of aggressive head and neck cancers with early age onsets. Their recently identified genomic landscapes by whole-exome sequencing (WES) clearly reveal critical roles of: (1) inflammation via NF-kB activation, (2) survival via PI3K aberrations, and perhaps (3) immune evasion via MHC loss in these cancers as summarized in this review. Immediate outcomes of these WES studies include the identification of potential prognostic biomarkers, and druggable events for these cancers. The impact of these genomic findings on the development of precision medicine and immunotherapies will be discussed. For both of these cancers, the main lethality comes from metastases and disease recurrences which may represent therapy resistance. Thus, potential curing of these cancers still relies on future identification of key genomic drivers and likely druggable events in recurrent and metastatic forms of these intrinsically aggressive cancers of the head and neck.
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影响因子：
16.6
作者：
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通讯作者：
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作者：
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