Influence of atopic dermatitis on reproduction and uterine natural killer cells.
Influence of atopic dermatitis on reproduction and uterine natural killer cells.
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DOI：
10.1292/jvms.13-0547
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发表时间：
2014-06
期刊：
影响因子：
--
通讯作者：
Kiso Y
中科院分区：
文献类型：
--
作者：
Hayashi K;Kusakabe KT;Sugimoto S;Wakitani S;Sugi S;Kuniyoshi N;Hiyama M;Takeshita A;Kano K;Kiso Y
严重过敏性疾病与成功怀孕之间的因果关系尚不清楚。我们的目的是评估特应性疾病(AD)实验性小鼠模型的生殖性能，并检测在胎盘形成中起关键作用的子宫自然杀伤(Unk)细胞的出现。在皮肤中度变态反应和血浆IgE升高8.6倍的NC/NGA妊娠小鼠中，正常胎儿数、流产率和胎盘大小的生殖指标没有显著差异。AD小鼠胎盘中Unk细胞较少，未成熟亚型的Unk细胞较对照组明显减少。这些发现表明，AD扰乱了Unk细胞的分化，并对胎盘形成产生不利影响，尽管它不会阻止妊娠过程。这可能是AD背后的特定免疫条件对生殖性能的恢复有利。
The causal relationship between severe allergic conditions and successful pregnancy remains unclear. We aimed to evaluate reproductive performance in an experimental mouse model of atopic disease (AD), and the appearance of uterine natural killer (uNK) cells that have crucial roles in placental formation was examined. In the NC/Nga pregnant mice with moderate skin allergic lesions and an 8.6-fold elevation of plasma IgE, significant differences were not detected in the reproductive indices of the number of normal fetuses, abortion rate and placental size. There were few uNK cells in the placenta of AD mice, and they showed a significant decrease regarding the immature subtype as compared with controls. These findings revealed that AD disturbs uNK cell differentiation and provides disadvantageous effects on placental formation, although it does not arrest the pregnancy process. It may be possible that specific immunological conditions behind AD operate favorably to recover the reproductive performance.
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影响因子：
2.8
作者：
Kusakabe, K;Li, ZL;Otsuki, Y
通讯作者：
Otsuki, Y
影响因子：
1.8
作者：
Kusakabe, K;Otsuki, Y;Kiso, Y
通讯作者：
Kiso, Y
DOI：
10.1590/s0104-42302005000300020
发表时间：
2005-06-01
期刊：
Revista da Associação Médica Brasileira
影响因子：
--
作者：
Zac, Renata Indelicato;Machado, Valeska Marques de Menezes;Petroianu, Andy
通讯作者：
Petroianu, Andy
影响因子：
3.8
作者：
Monk, JM;Leonard, S;Croy, BA
通讯作者：
Croy, BA
影响因子：
3.6
作者：
Kruse, A;Martens, N;Butcher, EC
通讯作者：
Butcher, EC