Role of Kinins in Hypertension and Heart Failure.
Role of Kinins in Hypertension and Heart Failure.
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DOI：
10.3390/ph13110347
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发表时间：
2020-10-28
期刊：
影响因子：
--
通讯作者：
Rhaleb NE
中科院分区：
文献类型：
--
作者：
Hamid S;Rhaleb IA;Kassem KM;Rhaleb NE
激肽释放酶-激动素系统(KKS)被认为是对血管加压激素系统(如肾素-血管紧张素系统(RAS)、醛固酮和儿茶酚胺)的反向调节系统。有证据支持这样的观点，即KKS不仅对血压至关重要，而且可能还反对靶器官损伤。激肽原是由组织和血浆激肽释放酶生成的。基于KKS的人类突变案例或激肽原基因序列自发突变的大鼠，以及仅表达KKS的一个组分的基因缺失或过度表达的小鼠模型，讨论了激肽在高血压发病中的可能作用。激动素的一些作用是通过激活B2和/或B1受体和下游信号如二十烷基类化合物、一氧化氮(NO)、内皮衍生超极化因子(EDHF)和/或组织纤溶酶原激活物(T-PA)来实现的。由于来自不同实验室的相互矛盾的报告，激肽在正常或高血压条件下的血压调节中的作用仍然存在争议。然而，已发表的关于激肽对缺血和心脏预适应的保护和中介作用的报道是一致的；报道还显示了激肽在血管紧张素转换酶(ACE)和血管紧张素1型受体阻滞剂(ARB)的心血管保护作用中的作用。
The kallikrein–kinin system (KKS) is proposed to act as a counter regulatory system against the vasopressor hormonal systems such as the renin-angiotensin system (RAS), aldosterone, and catecholamines. Evidence exists that supports the idea that the KKS is not only critical to blood pressure but may also oppose target organ damage. Kinins are generated from kininogens by tissue and plasma kallikreins. The putative role of kinins in the pathogenesis of hypertension is discussed based on human mutation cases on the KKS or rats with spontaneous mutation in the kininogen gene sequence and mouse models in which the gene expressing only one of the components of the KKS has been deleted or over-expressed. Some of the effects of kinins are mediated via activation of the B2 and/or B1 receptor and downstream signaling such as eicosanoids, nitric oxide (NO), endothelium-derived hyperpolarizing factor (EDHF) and/or tissue plasminogen activator (T-PA). The role of kinins in blood pressure regulation at normal or under hypertension conditions remains debatable due to contradictory reports from various laboratories. Nevertheless, published reports are consistent on the protective and mediating roles of kinins against ischemia and cardiac preconditioning; reports also demonstrate the roles of kinins in the cardiovascular protective effects of the angiotensin-converting enzyme (ACE) and angiotensin type 1 receptor blockers (ARBs).
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影响因子：
9.3
作者：
Talbot S;De Brito Gariépy H;Saint-Denis J;Couture R
通讯作者：
Couture R
影响因子：
8.3
作者：
Abadir, Peter M.;Periasamy, Ammasi;Siragy, Helmy M.
通讯作者：
Siragy, Helmy M.
DOI：
10.1016/0304-4165(81)90262-2
发表时间：
1981-01-01
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
ALHENCGELAS, F;MARCHETTI, J;MENARD, J
通讯作者：
MENARD, J
影响因子：
8.3
作者：
Azizi, M;Ezan, E;Ménard, J
通讯作者：
Ménard, J
影响因子：
7.3
作者：
Belichard, P;Loillier, B;Pruneau, D
通讯作者：
Pruneau, D