Therapeutic potential and challenges of bitter taste receptors on lung cells.
Therapeutic potential and challenges of bitter taste receptors on lung cells.
复制标题
DOI：
10.1016/j.coph.2020.07.004
复制
发表时间：
2020-04
影响因子：
4
通讯作者：
Deshpande DA
中科院分区：
文献类型：
--
作者：
Conaway S Jr;Nayak AP;Deshpande DA
Airway smooth muscle (ASM) hyperresponsiveness and airway remodeling are pathological drivers of disease progression and mortality in asthma. Importantly, approximately 50% of affected individuals are unable to reliably manage disease symptoms using the current standard of care. Recently, T2Rs have been identified as a novel class of G protein-coupled receptors expressed in the airway that on activation can induce ASM relaxation and reduction in airway tone. Further, agonists of T2Rs may also remedy airway remodeling, which has been difficult to manage with currently available medications. In this review, we will discuss the recent developments in T2R biology and their role in cellular physiology (particularly ASM) and expand on the therapeutic potential of T2R agonists in treatment of asthma.
登录
查看更多内容
影响因子：
3.7
作者：
Camoretti-Mercado B;Pauer SH;Yong HM;Smith DC;Deshpande DA;An SS;Liggett SB
通讯作者：
Liggett SB
影响因子：
24.3
作者：
Hall, IP
通讯作者：
Hall, IP
气道平滑肌上的苦味受体通过局部钙信号传导和反向阻塞来支气管扩张。
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
4.6
作者：
Sharma P;Yi R;Nayak AP;Wang N;Tang F;Knight MJ;Pan S;Oliver B;Deshpande DA
通讯作者：
Deshpande DA
影响因子：
3.5
作者：
Di Pizio, Antonella;Niv, Masha Y.
通讯作者：
Niv, Masha Y.