Human cancer classification: a systems biology- based model integrating morphology, cancer stem cells, proteomics, and genomics.
Human cancer classification: a systems biology- based model integrating morphology, cancer stem cells, proteomics, and genomics.
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DOI：
10.7150/jca.2.107
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发表时间：
2011-02-22
影响因子：
3.9
通讯作者：
Idikio HA
中科院分区：
文献类型：
--
作者：
Idikio HA
目前，人类癌症分类是基于细胞起源、癌症的光镜和电镜属性的想法。尚未纳入癌症分类的是这些癌细胞的功能属性。最近的生物学创新技术提供了大量关于癌细胞基因组、转录组和蛋白质组变化的信息。癌症干细胞概念的出现需要纳入分类模型中，以捕获癌症干细胞的已知属性及其对治疗反应和转移的潜在贡献。这里提出的癌症分类的综合模型结合了癌症的所有形态学、癌症干细胞贡献、遗传和功能属性。综合癌症分类模型可以消除目前分类中使用的不可分类的癌症。未来的癌症治疗可能会通过使用癌症分类的综合模型来推进。
Human cancer classification is currently based on the idea of cell of origin, light and electron microscopic attributes of the cancer. What is not yet integrated into cancer classification are the functional attributes of these cancer cells. Recent innovative techniques in biology have provided a wealth of information on the genomic, transcriptomic and proteomic changes in cancer cells. The emergence of the concept of cancer stem cells needs to be included in a classification model to capture the known attributes of cancer stem cells and their potential contribution to treatment response, and metastases. The integrated model of cancer classification presented here incorporates all morphology, cancer stem cell contributions, genetic, and functional attributes of cancer. Integrated cancer classification models could eliminate the unclassifiable cancers as used in current classifications. Future cancer treatment may be advanced by using an integrated model of cancer classification.
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影响因子：
64.8
作者：
Di Micco, Raffaella;Fumagalli, Marzia;di Fagagna, Fabrizio d'Adda
通讯作者：
di Fagagna, Fabrizio d'Adda
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
64.8
作者：
通讯作者：
--
DOI：
10.1073/pnas.0702165104
发表时间：
2007-05-29
影响因子：
11.1
作者：
Dahl, Fredrik;Stenberg, Johan;Ji, Hanlee
通讯作者：
Ji, Hanlee
影响因子：
11.5
作者：
Amaravadi, Ravi K.;Thompson, Craig B.
通讯作者：
Thompson, Craig B.