What are infant siblings teaching us about autism in infancy?
What are infant siblings teaching us about autism in infancy?
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DOI：
10.1002/aur.81
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发表时间：
2009-06
期刊：
影响因子：
4.7
通讯作者：
Rogers, Sally J.
中科院分区：
文献类型：
--
作者：
Rogers, Sally J.
了解自闭症谱系障碍的婴儿发展模式的国际研究最近集中在一个研究范式，涉及自闭症儿童的婴儿兄弟姐妹的前瞻性纵向研究。这种设计使用没有任何家族风险的婴儿兄弟姐妹的对照组（低风险组）来收集关于生命前三年发育技能的纵向信息，然后在36个月时进行ASD的临床诊断。本文综述了五个主题：ASD在婴儿兄弟姐妹群体中的存在，运动发育的模式和特征，社会和情感发展的模式和特征，有意沟通的模式和特征，包括语言和非语言，以及标志着ASD发病的行为特征的模式。在所有这些领域的症状通常开始在12 - 24个月的年龄段期间被检测到的婴儿谁将发展自闭症。症状的发作发生在不同的年龄和不同的模式，但在这些婴儿兄弟姐妹前瞻性研究中，很少报告从以前的回顾性研究中报告的20-30%的儿童的技能和明显的退化的模式坦率的损失。两个惊喜涉及非常早期的重复和不寻常的感觉行为，以及缺乏6个月大的预测症状。与目前认为自闭症是一种从生命最初几个月起就深刻影响社会发展的疾病相反，这些研究的数据显示自闭症是一种涉及多个领域症状的疾病，其症状是逐渐发作的，会改变持续的发展速度和建立的行为模式。
International research to understand infant patterns of development in autism spectrum disorders has recently focused on a research paradigm involving prospective longitudinal studies of infant siblings of children with autism. Such designs use a comparison group of infant siblings without any familial risks (the low- risk group) to gather longitudinal information about developmental skills across the first three years of life, followed by clinical diagnosis of ASD at 36 months. This review focuses on five topics: presence of ASD in the infant sibling groups, patterns and characteristics of motor development, patterns and characteristics of social and emotional development, patterns and characteristics of intentional communication, both verbal and nonverbal, and patterns that mark the onset of behaviors pathognomonic for ASD. Symptoms in all these areas typically begin to be detected during the age period of 12 –24 months in infants who will develop autism. Onset of the symptoms occurs at varying ages and in varying patterns, but the pattern of frank loss of skills and marked regression reported from previous retrospective studies in 20–30% of children is seldom reported in these infant sibling prospective studies. Two surprises involve the very early onset of repetitive and unusual sensory behaviors, and the lack of predictive symptoms at age 6 months. Contrary to current views that autism is a disorder that profoundly affects social development from the earliest months of life, the data from these studies presents a picture of autism as a disorder involving symptoms across multiple domains with a gradual onset that changes both ongoing developmental rate and established behavioral patterns across the first two to three years of life.
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DOI：
10.1111/j.1469-7610.2006.01531.x
发表时间：
2006-06-01
影响因子：
7.6
作者：
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通讯作者：
Garrett-Mayer, Elizabeth
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Rogers, Sally J.
影响因子：
3.9
作者：
ADRIEN, JL;FAURE, M;SAUVAGE, D
通讯作者：
SAUVAGE, D
影响因子：
3.9
作者：
Goldberg, WA;Jarvis, KL;Spence, MA
通讯作者：
Spence, MA