Long non-coding RNAs: Promising new targets in pulmonary fibrosis.
Long non-coding RNAs: Promising new targets in pulmonary fibrosis.
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DOI：
10.1002/jgm.3318
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Song X
中科院分区：
文献类型：
--
作者：
Zhang S;Chen H;Yue D;Blackwell TS;Lv C;Song X
肺纤维化的特点是肺部进行性且不可逆的疤痕，预后和治疗都很差。它是由多种因素引起的，包括环境和职业暴露以及一些风湿免疫疾病。即使COVID-19大流行在全球迅速蔓延，也很有可能导致肺纤维化。长非编码 RNA (lncRNA) 的功能使其成为纤维增生性疾病的极具吸引力的诊断和治疗靶点。因此，迫切需要了解lncRNA调节肺纤维化发病机制的具体机制，以确定新的治疗可能性。在这篇综述中，我们重点关注肺纤维化过程中lncRNA靶向蛋白编码和非编码基因的分子机制和意义，并系统分析lncRNA与各种类型RNA（包括microRNA、环状RNA和mRNA）的通讯。最后，我们提出了基于 lncRNA 的肺纤维化诊断和治疗的潜在方法。我们希望了解蛋白质编码基因和非编码基因之间的相互作用将有助于开发基于 lncRNA 的肺纤维化临床应用。不同的非编码RNA（lncRNA）由于其细胞定位而表现出不同的调节机制，这反过来又导致它们在疾病发生和进展中的功能差异。这篇综述重点介绍了 lncRNA 如何促进肺纤维化。
Pulmonary fibrosis is characterized by progressive and irreversible scarring in the lungs with poor prognosis and treatment. It is caused by various factors, including environmental and occupational exposures, and some rheumatic immune diseases. Even the rapid global spread of the COVID‐19 pandemic can also cause pulmonary fibrosis with a high probability. Functions attributed to long non‐coding RNAs (lncRNAs) make them highly attractive diagnostic and therapeutic targets in fibroproliferative diseases. Therefore, an understanding of the specific mechanisms by which lncRNAs regulate pulmonary fibrotic pathogenesis is urgently needed to identify new possibilities for therapy. In this review, we focus on the molecular mechanisms and implications of lncRNAs targeted protein‐coding and non‐coding genes during pulmonary fibrogenesis, and systematically analyze the communication of lncRNAs with various types of RNAs, including microRNA, circular RNA and mRNA. Finally, we propose the potential approach of lncRNA‐based diagnosis and therapy for pulmonary fibrosis. We hope that understanding these interactions between protein‐coding and non‐coding genes will contribute to the development of lncRNA‐based clinical applications for pulmonary fibrosis. Different non‐coding RNAs (lncRNAs) exhibit different regulatory mechanisms because of their cellular localization, which, in turn, leads to their functional divergence in disease occurrence and progression. This review highlights how lncRNAs contribute to pulmonary fibrogenesis.
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发表时间：
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影响因子：
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