Metallothionein-II inhibits lipid peroxidation and improves functional recovery after transient brain ischemia and reperfusion in rats.
Metallothionein-II inhibits lipid peroxidation and improves functional recovery after transient brain ischemia and reperfusion in rats.
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DOI：
10.1155/2014/436429
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发表时间：
2014
影响因子：
--
通讯作者：
Rios C
中科院分区：
文献类型：
--
作者：
Diaz-Ruiz A;Vacio-Adame P;Monroy-Noyola A;Méndez-Armenta M;Ortiz-Plata A;Montes S;Rios C
After transient cerebral ischemia and reperfusion (I/R), damaging mechanisms, such as excitotoxicity and oxidative stress, lead to irreversible neurological deficits. The induction of metallothionein-II (MT-II) protein is an endogenous mechanism after I/R. Our aim was to evaluate the neuroprotective effect of MT-II after I/R in rats. Male Wistar rats were transiently occluded at the middle cerebral artery for 2 h, followed by reperfusion. Rats received either MT (10 μg per rat i.p.) or vehicle after ischemia. Lipid peroxidation (LP) was measured 22 h after reperfusion in frontal cortex and hippocampus; also, neurological deficit was evaluated after ischemia, using the Longa scoring scale. Infarction area was analyzed 72 hours after ischemia. Results showed increased LP in frontal cortex (30.7%) and hippocampus (26.4%), as compared to control group; this effect was fully reversed by MT treatment. Likewise, we also observed a diminished neurological deficit assessed by the Longa scale in those animals treated with MT compared to control group values. The MT-treated group showed a significant (P < 0.05) reduction of 39.9% in the infarction area, only at the level of hippocampus, as compared to control group. Results suggest that MT-II may be a novel neuroprotective treatment to prevent ischemia injury.
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影响因子：
3.8
作者：
KERSHAW, WC;KLAASSEN, CD
通讯作者：
KLAASSEN, CD
影响因子：
2
作者：
Lewis, Katherine E.;Chung, Roger S.;Chuah, Meng Inn
通讯作者：
Chuah, Meng Inn
影响因子：
2.5
作者：
SANTAMARIA, A;RIOS, C
通讯作者：
RIOS, C
DOI：
10.1111/j.1440-1681.2009.05279.x
发表时间：
2010-02-01
影响因子：
2.9
作者：
Xia, Weiliang;Han, Jin;Ying, Weihai
通讯作者：
Ying, Weihai
影响因子：
4.4
作者：
Lee, Jae Hoon;Cui, Hui Song;Koo, Bon-Nyeo
通讯作者：
Koo, Bon-Nyeo