Magnesium Deficiency and Cardiometabolic Disease.

Magnesium Deficiency and Cardiometabolic Disease.
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DOI:
10.3390/nu15102355
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发表时间:
2023-05-17
期刊:
影响因子:
5.9
通讯作者:
Stewart AJ
Stewart AJ
中科院分区:
医学2区
文献类型:
--
作者:
Fritzen R;Davies A;Veenhuizen M;Campbell M;Pitt SJ;Ajjan RA;Stewart AJ

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镁(Mg 2+)在人体内具有多种生理功能。这些包括在维持心血管功能方面的重要作用,其中它有助于调节心脏兴奋-收缩偶联、内皮功能和止血。Mg 2+的止血作用影响凝血的蛋白质和细胞臂。在这篇综述中,我们研究了Mg 2+如何在体内维持动态平衡,并强调了Mg 2+在心血管系统中的各种分子作用。此外,我们描述了在某些代谢条件下,营养和/或疾病相关的镁缺乏症如何影响心脏和血管结局。最后,我们还研究了镁补充剂用于预防和治疗心血管疾病以及管理心脏代谢健康的潜力。
Magnesium (Mg2+) has many physiological functions within the body. These include important roles in maintaining cardiovascular functioning, where it contributes to the regulation of cardiac excitation–contraction coupling, endothelial functioning and haemostasis. The haemostatic roles of Mg2+ impact upon both the protein and cellular arms of coagulation. In this review, we examine how Mg2+ homeostasis is maintained within the body and highlight the various molecular roles attributed to Mg2+ in the cardiovascular system. In addition, we describe how nutritional and/or disease-associated magnesium deficiency, seen in some metabolic conditions, has the potential to influence cardiac and vascular outcomes. Finally, we also examine the potential for magnesium supplements to be employed in the prevention and treatment of cardiovascular disorders and in the management of cardiometabolic health.
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