Beyond growth: novel functions for bacterial cell wall hydrolases.

Beyond growth: novel functions for bacterial cell wall hydrolases.
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DOI:
10.1016/j.tim.2012.08.003
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发表时间:
2012-11
影响因子:
15.9
通讯作者:
Salama, Nina R.
Salama, Nina R.
中科院分区:
生物学1区
文献类型:
--
作者:
Wyckoff, Timna J.;Taylor, Jennifer A.;Salama, Nina R.

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The peptidoglycan cell wall maintains turgor pressure and cell shape of most bacteria. Cell wall hydrolases are essential, along with synthases, for growth and daughter cell separation. Recent work in diverse organisms has uncovered new cell wall hydrolases that act autonomously or on neighboring cells to modulate invasion of prey cells, cell shape, innate immune detection, intercellular communication, and competitor lysis. The hydrolases involved in these processes catalyze the cleavage of bonds throughout the sugar and peptide moities of peptidoglycan. Phenotypes associated with these diverse hydrolases reveal new functions of the bacterial cell wall beyond growth and division.
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