Age-Related Hearing Loss and Its Association with Depression in Later Life.
Age-Related Hearing Loss and Its Association with Depression in Later Life.
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DOI：
10.1016/j.jagp.2018.04.003
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发表时间：
2018-07
期刊：
影响因子：
--
通讯作者：
Rutherford BR
中科院分区：
文献类型：
--
作者：
Brewster KK;Ciarleglio A;Brown PJ;Chen C;Kim HO;Roose SP;Golub JS;Rutherford BR
评估老年人年龄相关性听力损失（ARHL）与抑郁症状之间的关系。来自健康老龄化和身体组成研究（N=3075，基线年龄70-79岁）的数据先前被用于进行纵向潜在类分析，以评估10年来的抑郁轨迹（流行病学研究中心抑郁[CES-D]量表）。局限于有听力信息的受试者子集（N=1204），在同一时期对自我报告的听力类别进行评估。通过多项逻辑回归分析评估抑郁类别与听力类别之间的关系。相关分析和双样本t检验用于评估抑郁状态和听力测量之间的横断面关联。低概率（N=644）、增加概率（N=385）和高概率（N=175）的抑郁症状轨迹在10年期间被确定。使用自我报告定义听力受损/恶化（N=182）和健康/改善（N=1,022）类别。以低概率抑郁轨迹为参照组，报告听力受损/恶化的受试者出现增加-的几率增加1.63倍（p=0.0088, 95% CI[1.13, 2.34]），出现高概率抑郁轨迹的几率增加1.85倍（p=0.0102, 95% CI[1.16, 2.96]）。在第5年，与10CES-D < 10的个体相比，抑郁症状（10CES-D≥10）个体的低频（校正平均差值=2.29 dBHL,p= 0.0005）和中频声音（校正平均差值=2.28 dBHL,p=0.0049）的听力能力受损。ARHL与老年人抑郁症状增加有关。未来的研究应该调查ARHL的治疗是否可能是一种有效的预防和/或治疗抑郁症状的策略。
To evaluate the association between age-related hearing loss (ARHL) and depressive symptoms in older adults over time. Data from the Health Aging and Body Composition study (N=3075, aged 70–79 at baseline) were used previously to conduct a longitudinal latent class analysis to evaluate depression trajectories (Center for Epidemiologic Studies Depression [CES-D] Scale) over 10 years. Restricting to the subset of subjects who had hearing information available (N=1204), self-reported hearing categories were evaluated over the same period. Association between depression classes and hearing categories were assessed via multinomial logistic regression analyses. Correlation analyses and two-sample t-tests were used to assess cross-sectional associations between depression status and audiometric hearing measures. Low-probability (N=644), increasing-probability (N=385), and high-probability (N=175) trajectories of depressive symptoms were identified for the 10-year period. Impaired/Worsening (N=182) and Healthy/Improving (N=1,022) hearing categories were defined using self-reports. With the low-probability depression trajectory as the reference group, subjects reporting Impaired/Worsening hearing had 1.63 times increased odds of having an increasing- (p=0.0088, 95% CI [1.13, 2.34]) and 1.85 times increased odds of having a high-probability depression trajectory (p=0.0102, 95% CI [1.16, 2.96]). At Year 5, individuals with depressive symptoms (10CES-D≥10) had impaired hearing ability measured by audiometric threshold for low-frequency (Adjusted mean difference=2.29 dBHL, p=0.0005) and mid-frequency sounds (Adjusted mean difference=2.28 dBHL,p=0.0049) compared to those with 10CES-D < 10. ARHL was associated with increased depressive symptoms in older adults. Future studies should investigate whether treatment of ARHL may be an effective prevention and/or therapeutic strategy for depressive symptoms.
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