Hearing loss and incident dementia.
Hearing loss and incident dementia.
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DOI：
10.1001/archneurol.2010.362
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发表时间：
2011-02
影响因子：
--
通讯作者：
Ferrucci, Luigi
中科院分区：
文献类型：
--
作者：
Lin, Frank R.;Metter, E. Jeffrey;O'Brien, Richard J.;Resnick, Susan M.;Zonderman, Alan B.;Ferrucci, Luigi
早期研究表明，在60岁以上成年人中患病率超过30%的听力损失可能是痴呆的一个风险因素，但这一假设从未经过前瞻性研究。
为了确定听力损失是否与全因痴呆和阿尔茨海默病（AD）的发病相关。
对巴尔的摩衰老纵向研究中的639名参与者（年龄36 - 90岁）进行前瞻性研究，这些参与者在1990 - 1994年期间接受了听力测试且无痴呆。听力损失是根据听力较好的耳朵在0.5、1、2和4 kHz的听力阈值纯音平均值来定义的（正常<25 dB [n = 455]，轻度损失25 - 40 dB [n = 125]，中度损失41 - 70 dB [n = 53]，重度损失>70 dB [n = 6]）。发病痴呆的诊断是通过共识诊断会议做出的。考克斯比例风险模型用于根据听力损失的严重程度对发病痴呆的时间进行建模，并对年龄、性别、种族、教育程度、糖尿病、吸烟和高血压进行了调整。
直至2008年5月31日的全因痴呆和AD的发病率。
在中位随访11.9年期间，诊断出58例全因痴呆发病病例，其中37例为AD。全因痴呆发病风险随基线听力损失的严重程度呈对数线性增加（每10 dB损失为1.27，95%置信区间：1.06 - 1.50）。与正常听力相比，轻度听力损失的全因痴呆发病风险比为1.89（95%置信区间：1.00 - 3.58），中度听力损失为3.00（95%置信区间：1.43 - 6.30），重度听力损失为4.94（95%置信区间：1.09 - 22.4）。AD发病风险也随基线听力损失而增加，但置信区间更宽（每10 dB听力损失为1.20，95%置信区间：0.94 - 1.53）。
听力损失与全因痴呆发病独立相关。听力损失是早期痴呆的一个标志物，还是实际上是痴呆的一个可改变的风险因素，值得进一步研究。
Earlier studies have suggested that hearing loss, which is prevalent in more than 30% of adults >60 years, may be a risk factor for dementia, but this hypothesis has never been investigated prospectively. To determine if hearing loss is associated with incident all-cause dementia and Alzheimer’s disease (AD). Prospective study of 639 participants (age 36 – 90 y) of the Baltimore Longitudinal Study of Aging who had audiometric testing and who were dementia-free in 1990-1994. Hearing loss was defined by a pure-tone average of hearing thresholds at 0.5, 1, 2, and 4 kHz in the better-hearing ear (normal <25 dB [n = 455], mild loss 25-40 dB [n = 125], moderate loss 41-70 dB [n = 53], severe loss >70 dB [n = 6]). Diagnosis of incident dementia was made by consensus diagnostic conference. Cox proportional hazard models were used to model time to incident dementia according to severity of hearing loss and were adjusted for age, sex, race, education, diabetes, smoking, and hypertension. Incidence of all-cause dementia and AD until May 31, 2008. During a median follow-up of 11.9 years, 58 cases of incident all-cause dementia were diagnosed of which 37 cases were AD. The risk of incident all-cause dementia increased log-linearly with the severity of baseline hearing loss (1.27 per 10 db loss, 95% CI: 1.06 – 1.50). Compared to normal hearing, the hazard ratio for incident all-cause dementia was 1.89 for mild hearing loss (95% CI: 1.00 – 3.58), 3.00 for moderate hearing loss (95% CI: 1.43 – 6.30), and 4.94 for severe hearing loss (95% CI: 1.09 – 22.4). The risk of incident AD also increased with baseline hearing loss but with a wider confidence interval (1.20 per 10 dB of hearing loss, 95% CI: 0.94 – 1.53). Hearing loss is independently associated with incident all-cause dementia. Whether hearing loss is a marker for early stage dementia or is actually a modifiable risk factor for dementia deserves further study.
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影响因子：
168.9
作者：
Fratiglioni, L;Wang, HX;Winblad, B
通讯作者：
Winblad, B
影响因子：
14
作者：
Brookmeyer, Ron;Johnson, Elizabeth;Arrighi, H. Michael
通讯作者：
Arrighi, H. Michael
影响因子：
9.9
作者：
Kawas, C;Gray, S;Zonderman, A
通讯作者：
Zonderman, A
DOI：
10.1682/jrrd.2005.01.0006
发表时间：
2005-07-01
影响因子：
--
作者：
Gordon-Salant, S
通讯作者：
Gordon-Salant, S
影响因子：
5.7
作者：
Dalton, DS;Cruickshanks, KJ;Nondahl, DM
通讯作者：
Nondahl, DM