Genetic modification of the effect of maternal household air pollution exposure on birth weight in Guatemalan newborns.
Genetic modification of the effect of maternal household air pollution exposure on birth weight in Guatemalan newborns.
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DOI：
10.1016/j.reprotox.2014.09.014
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发表时间：
2014-12
影响因子：
3.3
通讯作者：
Holland, Nina
中科院分区：
文献类型：
--
作者：
Thompson, Lisa M.;Yousefi, Paul;Penaloza, Renee;Balmes, John;Holland, Nina
关键词：
低出生体重与怀孕期间暴露于空气污染有关。本研究的目的是评估是否空多态性的谷胱甘肽S-转移酶（GST），特别是GSTM 1和GSTT 1基因的婴儿或母亲，修改高暴露于家庭空气污染（HAP）从烹饪火灾和出生体重之间的关联。危地马拉农村的孕妇被随机分配到烟囱炉或继续使用明火做饭。新生儿在出生后48小时内进行测量。132对母婴配对提供了婴儿基因型（n=130）和/或母亲基因型（n=116）。母亲GSTM 1缺失与144克（95%CI：-291，1）相关，母亲/婴儿GSTT 1缺失与155克（95%CI：-303，-8）出生体重下降相关。尽管随着GST基因表达数量的增加，新生儿体重有增加的趋势，但使用烟囱炉灶的影响并未得到证实。
Low birth weight is associated with exposure to air pollution during pregnancy. The purpose of this study was to evaluate whether null polymorphisms of Glutathione S-transferases (GSTs), specifically GSTM1 and GSTT1 genes in infants or mothers, modifies the association between high exposures to household air pollution (HAP) from cooking fires and birth weight. Pregnant women in rural Guatemala were randomized to receive a chimney stove or continue to use open fires for cooking. Newborns were measured within 48 hours of birth. 132 mother-infant pairs provided infant genotypes (n=130) and/or maternal genotypes (n=116). Maternal null GSTM1 was associated with a 144 gram (95% CI: -291, 1) and combined maternal/infant null GSTT1 was associated with a 155 gram (95% CI -303, -8) decrease in birth weight. Although there was a trend toward higher birth weights with increasing number of expressed GST genes, the effect modification by chimney stove use was not demonstrated.
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影响因子：
10.4
作者：
Bonjour S;Adair-Rohani H;Wolf J;Bruce NG;Mehta S;Prüss-Ustün A;Lahiff M;Rehfuess EA;Mishra V;Smith KR
通讯作者：
Smith KR
影响因子：
1.5
作者：
Bonner, James C.
通讯作者：
Bonner, James C.
影响因子：
3.4
作者：
Dix-Cooper, Linda;Eskenazi, Brenda;Smith, Kirk R.
通讯作者：
Smith, Kirk R.
影响因子：
--
作者：
Hiragi, Cassia De Oliveira;De Oliveira, Silviene Fabiana;Klautau-Guimaraes, Maria De Nazare
通讯作者：
Klautau-Guimaraes, Maria De Nazare
影响因子：
2.7
作者：
DARY, O;PINEDA, O;BELIZAN, JM
通讯作者：
BELIZAN, JM