Genome Reduction Is Associated with Bacterial Pathogenicity across Different Scales of Temporal and Ecological Divergence.
Genome Reduction Is Associated with Bacterial Pathogenicity across Different Scales of Temporal and Ecological Divergence.
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DOI：
10.1093/molbev/msaa323
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发表时间：
2021-04-13
影响因子：
10.7
通讯作者：
Weinert LA
中科院分区：
文献类型：
--
作者：
Murray GGR;Charlesworth J;Miller EL;Casey MJ;Lloyd CT;Gottschalk M;Tucker AWD;Welch JJ;Weinert LA
新出现的细菌病原体威胁全球健康和食品安全，因此，重要的是要问这些向致病性的转变是否有任何共同特征。我们对致病性与基因组减少和基因丢失有关的说法进行了系统的研究。我们比较了所有细菌的广泛模式，并对猪链球菌进行了详细分析，猪链球菌是一种新出现的猪的人畜共患病病原体，它已经在疾病和携带形式之间经历了多次过渡。我们发现，致病性与三个不同尺度上基因组大小的减小一致相关(属内物种之间，猪链球菌遗传集群之间和遗传集群内)。虽然互惠共生和共生细菌中也存在基因组减少，但病原菌的基因组减少不能完全归因于它们与这些物种共享的生态特征，即宿主限制或细胞内。此外，内共生菌基因组减少的其他典型相关性(代谢能力降低、GC含量降低和非功能元件的瞬时扩张)在病原体中并不一致。总之，我们的结果表明，基因组减少与细菌的致病性是一致的。
Emerging bacterial pathogens threaten global health and food security, and so it is important to ask whether these transitions to pathogenicity have any common features. We present a systematic study of the claim that pathogenicity is associated with genome reduction and gene loss. We compare broad-scale patterns across all bacteria, with detailed analyses of Streptococcus suis, an emerging zoonotic pathogen of pigs, which has undergone multiple transitions between disease and carriage forms. We find that pathogenicity is consistently associated with reduced genome size across three scales of divergence (between species within genera, and between and within genetic clusters of S. suis). Although genome reduction is also found in mutualist and commensal bacterial endosymbionts, genome reduction in pathogens cannot be solely attributed to the features of their ecology that they share with these species, that is, host restriction or intracellularity. Moreover, other typical correlates of genome reduction in endosymbionts (reduced metabolic capacity, reduced GC content, and the transient expansion of nonfunctional elements) are not consistently observed in pathogens. Together, our results indicate that genome reduction is a consistent correlate of pathogenicity in bacteria.
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