Factors driving effective population size and pan-genome evolution in bacteria.
Factors driving effective population size and pan-genome evolution in bacteria.
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DOI:
10.1186/s12862-018-1272-4
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发表时间:
2018-10-12
影响因子:
3.4
通讯作者:
Ochman H
中科院分区:
文献类型:
--
作者:
Bobay LM;Ochman H
Knowledge of population-level processes is essential to understanding the efficacy of selection operating within a species. However, attempts at estimating effective population sizes (Ne) are particularly challenging in bacteria due to their extremely large census populations sizes, varying rates of recombination and arbitrary species boundaries. In this study, we estimated Ne for 153 species (152 bacteria and one archaeon) defined under a common framework and found that ecological lifestyle and growth rate were major predictors of Ne; and that contrary to theoretical expectations, Ne was unaffected by recombination rate. Additionally, we found that Ne shapes the evolution and diversity of total gene repertoires of prokaryotic species. Together, these results point to a new model of genome architecture evolution in prokaryotes, in which pan-genome sizes, not individual genome sizes, are governed by drift-barrier evolution. The online version of this article (10.1186/s12862-018-1272-4) contains supplementary material, which is available to authorized users.
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