The Role of Perivascular Adipose Tissue in Non-atherosclerotic Vascular Disease.
The Role of Perivascular Adipose Tissue in Non-atherosclerotic Vascular Disease.
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DOI：
10.3389/fphys.2017.00969
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发表时间：
2017
影响因子：
4
通讯作者：
Weintraub NL
中科院分区：
文献类型：
--
作者：
Horimatsu T;Kim HW;Weintraub NL
血管周围脂肪组织（PVAT）围绕着大部分大血管，在血管内环境稳定中起着重要作用。PVAT释放各种趋化因子和脂肪细胞因子，以内分泌和旁分泌方式发挥作用以调节血管信号传导和炎症。越来越多的证据表明PVAT在动脉粥样硬化和高血压中起着重要作用;然而，PVAT在非动脉粥样硬化性血管疾病中的作用，包括新生内膜形成、主动脉瘤、动脉硬化和血管炎，受到的关注要少得多。越来越多的证据表明PVAT对机械性血管内损伤有反应，并通过促进平滑肌细胞生长、外膜炎症和新生血管形成的因子调节随后的新生内膜形成。间接证据还将PVAT与主动脉瘤和血管炎综合征（如Takayasu动脉炎）的发病机制联系起来，其中炎性细胞从PVAT浸润和迁移到血管壁中可能起到促进作用。此外，在肥胖症中，PVAT已经被牵涉到通过产生活性氧来促进弹性动脉的僵硬。本文将讨论越来越多的数据和机制PVAT的非动脉粥样硬化性血管疾病的发病机制在实验动物模型和人类。
Perivascular adipose tissue (PVAT) surrounds most large blood vessels and plays an important role in vascular homeostasis. PVAT releases various chemokines and adipocytokines, functioning in an endocrine and paracrine manner to regulate vascular signaling and inflammation. Mounting evidence suggests that PVAT plays an important role in atherosclerosis and hypertension; however, the role of PVAT in non-atherosclerotic vascular diseases, including neointimal formation, aortic aneurysm, arterial stiffness and vasculitis, has received far less attention. Increasing evidence suggests that PVAT responds to mechanical endovascular injury and regulates the subsequent formation of neointima via factors that promote smooth muscle cell growth, adventitial inflammation and neovascularization. Circumstantial evidence also links PVAT to the pathogenesis of aortic aneurysms and vasculitic syndromes, such as Takayasu's arteritis, where infiltration and migration of inflammatory cells from PVAT into the vascular wall may play a contributory role. Moreover, in obesity, PVAT has been implicated to promote stiffness of elastic arteries via the production of reactive oxygen species. This review will discuss the growing body of data and mechanisms linking PVAT to the pathogenesis of non-atherosclerotic vascular diseases in experimental animal models and in humans.
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影响因子：
7.8
作者：
Fleenor BS;Eng JS;Sindler AL;Pham BT;Kloor JD;Seals DR
通讯作者：
Seals DR
影响因子：
20.1
作者：
Chatterjee TK;Stoll LL;Denning GM;Harrelson A;Blomkalns AL;Idelman G;Rothenberg FG;Neltner B;Romig-Martin SA;Dickson EW;Rudich S;Weintraub NL
通讯作者：
Weintraub NL
影响因子：
37.8
作者：
Chang L;Villacorta L;Li R;Hamblin M;Xu W;Dou C;Zhang J;Wu J;Zeng R;Chen YE
通讯作者：
Chen YE
影响因子：
2.2
作者：
BUSUTTIL, RW;RINDERBRIECHT, H;CARMACK, C
通讯作者：
CARMACK, C
DOI：
10.1111/j.1749-6632.1999.tb07789.x
发表时间：
1999-01-01
期刊：
THE METABOLIC SYNDROME X
影响因子：
--
作者：
Daugherty, A;Cassis, L
通讯作者：
Cassis, L