New directions for the clathrin adaptor AP-1 in cell biology and human disease.
New directions for the clathrin adaptor AP-1 in cell biology and human disease.
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DOI:
10.1016/j.ceb.2022.102079
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发表时间:
2022-06
影响因子:
7.5
通讯作者:
Duncan, Mara C.
中科院分区:
文献类型:
--
作者:
Duncan, Mara C.
The clathrin adaptor protein complex-1 (AP-1) is a central player in cell physiology and human health. It is best known for its role in linking clathrin to its cargo at the trans-Golgi network and endosomes. It participates in traffic important for the correct function of a large number of organelles, including the trans-Golgi network, endosomes, lysosomes, lysosome-related organelles, and plasma membrane. Although it was one of the first clathrin adaptors identified, new discoveries about cargo and pathways that depend on AP-1 continue to emerge. This review summarizes new research into AP-1 that further illuminates its roles in the traffic of plasma membrane proteins, in maintaining TGN content, and in human disease.
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影响因子:
2.7
作者:
Buelto D;Hung CW;Aoh QL;Lahiri S;Duncan MC
通讯作者:
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DOI:
10.1083/jcb.201310021
发表时间:
2014-01-06
期刊:
The Journal of cell biology
影响因子:
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