Incretin-Based Therapies for Diabetic Complications: Basic Mechanisms and Clinical Evidence.
Incretin-Based Therapies for Diabetic Complications: Basic Mechanisms and Clinical Evidence.
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DOI：
10.3390/ijms17081223
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发表时间：
2016-07-29
影响因子：
5.6
通讯作者：
Utsunomiya K
中科院分区：
文献类型：
--
作者：
Kawanami D;Matoba K;Sango K;Utsunomiya K
与糖尿病并发症相关的发病率和死亡率的增加是全球关注的问题。血糖控制对于预防糖尿病并发症的发生和发展非常重要。目前有各种类型的抗糖尿病药物，并且已经研究了它们对糖尿病并发症的多效性作用。基于肠促胰岛素的治疗，如二肽基肽酶（DPP）-4抑制剂和胰高血糖素样肽-1受体激动剂（GLP-1 RA），目前广泛用于治疗2型糖尿病患者。一系列实验研究表明，肠促胰岛素治疗对糖尿病并发症具有有益作用，与其降糖能力无关，其由抗炎和抗氧化应激特性介导。基于这些发现，开展了评估DPP-4抑制剂和GLP-1 RA对糖尿病微血管和大血管并发症影响的临床研究。一些但并非所有研究都提供了证据，支持基于肠促胰岛素的治疗对2型糖尿病患者的糖尿病并发症的有益作用。我们在此讨论了基于肠促胰岛素治疗糖尿病并发症的实验和临床证据。
An increase in the rates of morbidity and mortality associated with diabetic complications is a global concern. Glycemic control is important to prevent the development and progression of diabetic complications. Various classes of anti-diabetic agents are currently available, and their pleiotropic effects on diabetic complications have been investigated. Incretin-based therapies such as dipeptidyl peptidase (DPP)-4 inhibitors and glucagon-like peptide-1 receptor agonists (GLP-1RA) are now widely used in the treatment of patients with type 2 diabetes. A series of experimental studies showed that incretin-based therapies have beneficial effects on diabetic complications, independent of their glucose-lowering abilities, which are mediated by anti-inflammatory and anti-oxidative stress properties. Based on these findings, clinical studies to assess the effects of DPP-4 inhibitors and GLP-1RA on diabetic microvascular and macrovascular complications have been performed. Several but not all studies have provided evidence to support the beneficial effects of incretin-based therapies on diabetic complications in patients with type 2 diabetes. We herein discuss the experimental and clinical evidence of incretin-based therapy for diabetic complications.
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影响因子：
5.8
作者：
Goncalves, A.;Leal, E.;Fernandes, R.
通讯作者：
Fernandes, R.
DOI：
10.1152/ajpregu.00569.2006
发表时间：
2007-02-01
影响因子：
2.8
作者：
Boerrigter, Guido;Costello-Boerrigter, Lisa C.;Burnett, John C., Jr.
通讯作者：
Burnett, John C., Jr.
影响因子：
7.7
作者：
Chia, Chee W.;Carlson, Olga D.;Egan, Josephine M.
通讯作者：
Egan, Josephine M.
影响因子：
7.7
作者：
Arakawa M;Mita T;Azuma K;Ebato C;Goto H;Nomiyama T;Fujitani Y;Hirose T;Kawamori R;Watada H
通讯作者：
Watada H
影响因子：
3.1
作者：
Gonçalves A;Ambrósio AF;Fernandes R
通讯作者：
Fernandes R