New developments in the pathogenesis of acute exacerbations of chronic obstructive pulmonary disease
New developments in the pathogenesis of acute exacerbations of chronic obstructive pulmonary disease
复制标题
慢性阻塞性肺疾病急性加重发病机制的新进展
DOI：
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发表时间：
2004
影响因子：
3.9
通讯作者：
S. Sethi
中科院分区：
文献类型：
--
作者：
S. Sethi
综述目的慢性阻塞性肺疾病急性加重是一个定义和理解不清的实体。更好的研究设计和新的研究方法的应用已经为这种常见临床综合征的发病机制提供了相当多的线索。炎症是慢性阻塞性肺疾病发病机制的重要组成部分，急性加重可能代表由一种或多种病原体引起的气道炎症急性增加。流行病学研究表明，环境颗粒物和气体污染物与慢性阻塞性肺病呼吸道症状和死亡率增加有关。细菌、病毒和非典型病原体单独或共同引起大多数急性加重。总结通过支气管镜检查、分子流行病学、免疫学和气道炎症研究的结果，现已确定相当比例的急性加重的细菌原因。未来的研究应侧重于与慢性阻塞性肺疾病急性加重相关的病原微生物的致病机制和宿主防御，以制定更好的治疗和预防策略。
Purpose of review Acute exacerbations of chronic obstructive pulmonary disease were a poorly defined and understood entity. The application of better study designs and new research methodologies has shed considerable light on the pathogenesis of this common clinical syndrome. Recent findings Inflammation is an important component of the pathogenesis of chronic obstructive pulmonary disease, and exacerbations probably represent acute increases in airway inflammation brought about by one or more etiological agents. Environmental particulate and gaseous pollutants have been linked in epidemiological studies with increased respiratory symptoms and mortality in chronic obstructive pulmonary disease. Bacterial, viral and atypical pathogens, either alone or in concert, induce the majority of acute exacerbations. Summary A bacterial cause of a substantial proportion of exacerbations is now firmly established by the results of bronchoscopy, molecular epidemiology, immunology and airway inflammation studies. Future research should focus on pathogenic mechanisms and host defence against the microbial pathogens associated with acute exacerbations of chronic obstructive pulmonary disease, in order to develop better treatment and prevention strategies.
DOI：
10.1164/ajrccm.164.11.2104093
发表时间：
2001-12-01
影响因子：
24.7
作者：
Bandi, V;Apicella, MA;Greenberg, SB
通讯作者：
Greenberg, SB