Nanobiotechnology for the Therapeutic Targeting of Cancer Cells in Blood.
Nanobiotechnology for the Therapeutic Targeting of Cancer Cells in Blood.
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DOI：
10.1007/s12195-015-0381-z
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发表时间：
2015
影响因子：
2.8
通讯作者：
King, Michael R.
中科院分区：
文献类型：
--
作者：
Li, Jiahe;Sharkey, Charles C.;Huang, Dantong;King, Michael R.
在转移过程中，循环肿瘤细胞通过血液循环从原发性肿瘤中迁移出来，在远处器官中形成继发性肿瘤。来自临床观察的越来越多的证据表明，血液中循环肿瘤细胞（CTC）的数量与化疗前和化疗期间实体瘤的进展相关。然而，除了CTC作为液体活检的公认作用之外，靶向CTC以预防或减少转移的领域刚刚出现。常规的癌症治疗剂在血液中具有相对短的循环时间，这可能由于CTC对药物的暴露减少而导致CTC的杀伤效率低下。尽管如此，在过去的几十年里，纳米颗粒和纳米制剂的开发可以改善流通中药物的半衰期和释放特性，使新兴的CTC中和领域的某些传统药物焕发了活力。这篇评论的重点是如何纳米医学的原则可能适用于目标CTC。此外，受血液循环中CTC与宿主细胞之间相互作用的启发，提出了用于靶向药物递送的新型仿生方法。
During metastasis, circulating tumor cells migrate away from a primary tumor via the blood circulation to form secondary tumors in distant organs. Mounting evidence from clinical observations indicates that the number of circulating tumor cells (CTCs) in the blood correlates with the progression of solid tumors before and during chemotherapy. Beyond the well-established role of CTCs as a fluid biopsy, however, the field of targeting CTCs for the prevention or reduction of metastases has just emerged. Conventional cancer therapeutics have a relatively short circulation time in the blood which may render the killing of CTCs inefficient due to reduced exposure of CTCs to drugs. Nevertheless, over the past few decades, the development of nanoparticles and nanoformulations to improve the half-life and release profile of drugs in circulation has rejuvenated certain traditional medicines in the emerging field of CTC neutralization. This review focuses on how the principles of nanomedicine may be applied to target CTCs. Moreover, inspired by the interactions between CTCs and host cells in the blood circulation, novel biomimetic approaches for targeted drug delivery are presented.
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